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-  2017 

脑性瘫痪婴儿的白质脑网络研究

DOI: doi:10.7507/1001-5515.201612044

Keywords: 脑性瘫痪, 弥散张量成像, 白质网络, 图论

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Abstract:

本文使用弥散张量成像及白质纤维束追踪技术构建和分析了 15 名脑性瘫痪患儿和 30 名正常婴儿大脑的白质脑网络,发现脑性瘫痪患儿和正常婴儿的白质脑网络都具有”小世界”属性,但患儿的最短路径长度明显变长,而标准聚类系数、全局效率和局部效率明显下降。此外,我们还发现左脑楔叶、左右脑楔前叶以及左脑扣带回后部是婴儿白质脑网络的核心节点,患儿白质脑网络的部分节点存在异常,且异常节点多集中于颞叶、枕叶和顶叶。本文结果表明脑性瘫痪婴儿的白质脑网络已经出现紊乱的现象,这为我们进一步研究脑性瘫痪儿童的发病机制提供了帮助

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