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-  2015 

青霉素生产菌-产黄青霉的蛋白质组学研究进展

DOI: doi:10.7507/1001-5515.20150239

Keywords: 青霉素, 产黄青霉, 蛋白质组, 蛋白质组学

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Abstract:

青霉素是世界上最早应用于临床治疗的β-内酰胺类药物, 目前仍被广泛应用。产黄青霉(P.Chrysogenum)是青霉素的生产菌, 其合成和调控机制已经研究得比较完善, 但在其蛋白质组学方面的研究起步较晚且相对较少。本文综述了青霉素的合成与应用, 以及产黄青霉的改造及其蛋白质组学的研究进展。在此基础上, 重点介绍了蛋白质组学对于研究菌株蛋白表达的优势

References

[1]  1. 刘丽华.β-内酰胺类抗生素的临床应用[J].中国药物经济学, 2013(6):245-246.
[2]  2. VAN DEN BERG M A. Functional characterisation of penicillin production strains[J]. Fungal Biol Rev, 2010, 24(1-2):73-78.
[3]  3. VOIGT K, KIRK P M. Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi:impact in applied microbiology and environmental biotechnology[J]. Appl Microbiol Biotechnol, 2011, 90(1):41-57.
[4]  4. SCHECKHUBER C Q, VEENHUIS M, VAN DER KLEI I J. Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction[J]. Metab Eng, 2013, 18:36-43.
[5]  5. OZCENGIZ G, DEMAIN A L. Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation[J]. Biotechnol Adv, 2013, 31(2):287-311.
[6]  6. VEIGA T, SOLIS-ESCALANTE D, ROMAGNOLI G, et al. Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum[J]. Eukaryot Cell, 2012, 11(2):238-249.
[7]  7. MARTíN J F, GARCíA-ESTRADA C, ULLáN R V. Transport of substrates into peroxisomes:the paradigm ofβ-lactam biosynthetic intermediates[J]. Biomol Concepts, 2013, 4(2):197-211.
[8]  8. FERNáNDEZ-AGUADO M, ULLáN R V, TEIJEIRA F, et al. The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum[J]. Appl Microbiol Biotechnol, 2013, 97(7):3073-3084.
[9]  9. 钱小红.定量蛋白质组学分析方法[J].色谱, 2013, 31(8):719-723.
[10]  10. 姜丽丽, 郝欣霞, 张东泽.有关蛋白质组学概述[J].内蒙古科技与经济, 2013, 277(3):108-109.
[11]  11. RAY S, REDDY P J, JAIN R, et al. Proteomic technologies for the identification of disease biomarkers in serum:advances and challenges ahead[J]. Proteomics, 2011, 11(11):2139-2161.
[12]  12. VILLANUEVA J, CARRASCAL M, ABIAN J. Isotope dilution mass spectrometry for absolute quantification in proteomics:Concepts and strategies[J]. J Proteomics, 2014, 96:184-199.
[13]  13. DíEZ P, DASILVA N, GONZáLEZ-GONZáLEZ M, et al. Data analysis strategies for protein microarrays[J]. Microarrays, 2012, 1(2):64-83.
[14]  22. 崔少飞.利迪链霉菌对外源谷氨酸和脯氨酸的代谢响应研究[D].天津:天津大学, 2013.
[15]  23. JAMI M S, BARREIRO C, GARCíA-ESTRADA C, et al. Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement[J]. Molecular & Cellular Proteomics, 2010, 9(6):1182-1198.
[16]  24. BARREIRO C, MARTíN J F, GARCíA-ESTRADA C. Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum[J]. J Biomed Biotechnol, 2012, 2012:105109.
[17]  25. GARCíA-ESTRADA C, BARREIRO C, JAMI M S, et al. The inducers 1, 3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction[J]. J Proteomics, 2013, 85:129-159.
[18]  26. MARTíN J, GARCíA-ESTRADA C, RUMBERO A, et al. Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum[J]. Appl Environ Microbiol, 2011, 77(16):5688-5696.
[19]  27. GOODMAN V, MVLLER A, GR?GER-ARNDT H, et al. Identification of spore specific allergens from Penicillium chrysogenum[J]. J Integr OMICS, 2011, 1(2):272-279.
[20]  28. JAMI M S, GARCíA-ESTRADA C, BARREIRO C, et al. The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology[J]. Mol Cell Proteomics, 2010, 9(12):2729-2744.
[21]  29. NICKEL W, RABOUILLE C. Mechanisms of regulated unconventional protein secretion[J]. Nat Rev Mol Cell Biol, 2009, 10(2):148-155.
[22]  20. 刘红, 刘艳, 谢丽萍, 等.顶头孢霉蛋白质组的制备[J].中国医药工业杂志, 2011, 42(6):412-415.
[23]  21. MARTíNEZ-ESTESO M J, VILELLA-ANTóN M T, PEDRE?O M A, et al. iTRAQ-based protein profiling provides insights into the central metabolism changes driving grape berry development and ripening[J]. BMC Plant Biol, 2013, 13(167):1-20.
[24]  30. KIEL J A, VAN DEN BERG M A, FUSETTI F, et al. Matching the proteome to the genome:the microbody of penicillin-producing Penicillium chrysogenum cells[J]. Funct Integr Genomics, 2009, 9(2):167-184.
[25]  14. 张莹, 杨芃原, 陆豪杰.基于多级质谱的蛋白质组定量新方法新技术进展[J].色谱, 2013, 31(6):503-509.
[26]  15. 袁建丰, 李林林, 孙敏华, 等.iTRAQ标记技术及其在微生物比较蛋白质组学中的研究进展[J].中国预防兽医学报, 2013, 35(10):859-862.
[27]  16. JIANG Yan, GUO Liang, XIE Li-qi, et al. Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS[J]. J Proteome Res, 2014, 13(3):1307-1314.
[28]  17. 胡彬彬, 林连兵, 魏云林, 等.一种高效的真菌总蛋白质提取方法[J].中国生物工程杂志, 2013, 33(9):53-58.
[29]  18. THIEDE B, KOEHLER C J, STROZYNSKI M, et al. High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture (SILAC), two-dimensional gel electrophoresis (2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer[J]. Mol Cell Proteomics, 2013, 12(2):529-538.
[30]  19. WU Xiaolin, GONG Fangping, WANG Wei. Protein extraction from plant tissues for 2DE and its application in proteomic analysis[J]. Proteomics, 2014, 14(6):645-658.

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