1. ？Papatriantafyllou M. The dual mucus defence. Nat Rev Immunol, 2013, 13(11): 774.
[2]
2. Button B, CAI L H, Ehre C, et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science, 2012, 337(697): 937-941.
[3]
3. Fahy J V, Dickey B F. Airway mucus function and dysfunction. N Engl J Med, 2010, 363(23): 2233-2247.
[4]
4. Lai S K, Wang Yingying, Wirtz D, et al. Micro- and macrorheology of mucus. Adv Drug Deliv Rev, 2009, 61(2): 86-100.
[5]
5. Johnson D C. Airway mucus function and dysfunction. N Engl J Med, 2011, 364(10): 978; author reply 978.
[6]
6. Kim W D. Lung mucus: a clinician's view. Eur Respir J, 1997, 10(8): 1914-1917.
[7]
7. Ohbayashi H, Setoguchi Y, Fukuchi Y, et al. Pharmacological effects of lysozyme on COPD and bronchial asthma with sputum: A randomized, placebo-controlled, small cohort, cross-over study. Pulm Pharmacol Ther, 2016, 37: 73-80.
[8]
8. Nordg？rd C, Nonstad U, Older？y M, et al. Alterations in mucus barrier function and matrix structure induced by guluronate oligomers. Biomacromolecules, 2014, 15(6): 2294-2300.
[9]
9. Hamed R, Fiegel J. Synthetic tracheal mucus with native rheological and surface tension properties. J Biomed Mater Res A, 2014, 102(6): 1788-1798.
[10]
10. Dickey B F. Walking on solid ground. Science, 2012, 337(697): 924-925.
[11]
11. Thornton D, Sheehan J. From mucins to mucus: toward a more coherent understanding of this essential barrier. Proc Am Thorac Soc, 2004, 1(1): 54-61.
[12]
12. Volsko T. Airway clearance therapy: finding the evidence. Respir Care, 2013, 58(10): 1669-1678.
[13]
13. Tomaiuolo G, Rusciano G, Caserta S, et al. A new method to improve the clinical evaluation of cystic fibrosis patients by mucus viscoelastic properties. PLoS One, 2014, 9(1): e82297.
[14]
14. Vasquez E S, Bowser J, Swiderski C A, et al. Rheological characterization of mammalian lung mucus. RSC Adv, 2014, 4(66): 34780-34783.
[15]
15. Mcgill S L, Smyth H D C. Disruption of the mucus barrier by topically applied exogenous particles. Mol Pharm, 2010, 7(6): 2280-2288.
[16]
16. Daviskas E, Rubin B K. Effect of inhaled dry powder mannitol on mucus and its clearance. Expert Rev Respir Med, 2013, 7(1): 65-75.
[17]
17. Chen E Y T, Wang Y C, Chen C S, et al. Functionalized positive nanoparticles reduce mucin swelling and dispersion// Aiche Meeting, 2010: e15434.
[18]
18. Wang Yingying, Lai S K, So C, et al. Mucoadhesive nanoparticles May disrupt the protective human mucus barrier by altering its microstructure. PLoS One, 2011, 6(6): e21547.
