肾小球滤过率（GFR）是评估肾脏功能的重要指标，可采用肾动态显像联合 Gates 法计算获得。针对 GFR 计算问题，本文提出一种计算机断层（CT）图像辅助的肾动态图像感兴趣区（ROI）自动检测方法，以实现客观准确的 GFR 计算。该方法首先获得 CT 冠状面投影图像与单光子发射计算机断层成像（SPECT）的增强合成图像，完成双模态图像配准后，采用改进的水平集方法实现肾脏 ROI 的自动检测并获取本底 ROI，最后利用 Gates 法计算 GFR 值。经临床数据验证，该方法能够自动完成肾脏 GFR 值计算，所得结果与临床报告一致。该方法在消除人工勾画环节的同时，还能提高 ROI 检测的准确性和稳定性，尤其有利于肾功能严重受损时的 GFR 计算
References
[1]
1. Zhang Luxia, Wang Fang, Wang Li, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet, 2012, 379(9818): 815-822.
[2]
2. Gates G F. Glomerular filtration rate: estimation from fractional renal accumulation of 99mTc-DTPA (stannous). Am J Roentgenol, 1982, 138(3): 565-570.
[3]
3. Gates G F. Split renal function testing using Tc-99m DTPA. A rapid technique for determining differential glomerular filtration. Clin Nucl Med, 1983, 8(9): 400-407.
[4]
4. Tomaru Y, Inoue T, Oriuchi N, et al. Semi-automated renal region of interest selection method using the double-threshold technique: inter-operator variability in quantitating 99mTc-MAG3 renal uptake. Eur J Nucl Med Mol Imaging, 1998, 25(1): 55-59.
[5]
5. Inoue Y, Yoshikawa K, Yoshioka N, et al. Evaluation of renal function with 99mTc-MAG3 using semiautomated regions of interest. J Nucl Med, 2000, 41(12): 1947-1954.
[6]
6. Garcia E V, Folks R, Pak S, et al. Totally automatic definition of renal regions of interest from 99mTc-MAG3 renograms: validation in patients with normal kidneys and in patients with suspected renal obstruction. Nucl Med Commun, 2010, 31(5): 366-374.
[7]
7. Tian Cancan, Zheng Xiujuan, Han Yuan, et al. A semi-automated region of interest detection method in the scintigraphic glomerular filtration rate determination for patients with abnormal low renal function. Clin Nucl Med, 2013, 38(11): 855-862.
9. Brix G, Nekolla E A, Borowski M, et al. Radiation risk and protection of patients in clinical SPECT/CT. Eur J Nucl Med Mol Imaging, 2014, 41(Suppl 1): S125-S136.
[10]
10. Buck A K, Nekolla S, Ziegler S, et al. SPECT/CT. J Nucl Med, 2009, 49(8): 1305-1319.
[11]
11. Tian Cancan, Huang Qiu, Han Yuan, et al. Validating CT-assisted region of interest acquisition method in 99mTc-DTPA scintigraphy for patients with low renal function. 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). Macao, China: IEEE, 2012: 955-958.
[12]
12. Li Chunming, Xu Chenyang, Gui Changfeng, et al. Distance regularized level set evolution and its application to image segmentation. IEEE Trans Image Process, 2010, 19(12): 3243-3254.
