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-  2017 

生物组织非接触光声层析成像

DOI: doi:10.7507/1001-5515.201603045

Keywords: 生物医学光学, 光声层析成像, 非接触, 生物组织

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Abstract:

在光声成像中,超声信号通常需要采用接触传感器探测,这使其在很多应用中受到很大的限制,如脑功能成像。为了替代接触探测器实现非接触的光声层析成像(NCPAT),激光干涉技术被用于远程获取超声信号。本文搭建了非接触光声层析成像系统,系统采用波长为 532 nm、能量 17.5 mJ/cm2 的激光作为光声激发源,激光外差干涉仪作为光声信号的远程探测系统,对实际生物组织模型进行了旋转几何的光声信号探测。利用激光外差干涉仪探测到的光声信号,进行反投影算法的图像重建。实验结果表明在具有组织散射特性的模型中,激光外差干涉仪在 2.25 MHz 带宽(峰值下 15 dB 强度的信号宽带)下,NCPAT 成像系统可以识别 500 μm 直径的黑色微球,并实现了在强散射介质中多层结构的光学对比成像。这将扩展光声和超声在体成像在生物医学领域的应用范围

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