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-  2018 

基于 theta-gamma 相位幅值耦合的脑疲劳信息传递整合机制研究

DOI: doi:10.7507/1001-5515.201703067

Keywords: 脑疲劳, 相位-幅值耦合, 脑电

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Abstract:

脑疲劳是长期脑力活动产生主观疲劳的状态,是影响脑力工作者健康的核心问题,但其对大脑信息传递整合过程的影响至今尚不清楚。因此本文采用相位–幅值耦合(PAC)方法对脑疲劳前后 theta 节律和 gamma 节律的脑电进行研究,以更好地解释脑疲劳对大脑信息传递机制的影响。实验采用 4 小时专业科技英语阅读诱发脑疲劳,利用脑电仪记录了 14 名男性在校本科生志愿者在脑疲劳前后的脑电信号。使用相位–幅值耦合方法进行分析,并对结果进行了t 检验。结果显示,全脑区域 90% 以上电极的 theta 相位共同调制右侧中央区和右侧顶叶区电极的 gamma 幅值,并且这种耦合作用在脑疲劳后显著下降(P < 0.05)。本研究表明 theta-gamma 之间的相位–幅值耦合变化能更好地解释脑疲劳对大脑信息传递整合机制的影响,有望成为一种新的脑疲劳检测指标,同时也为神经调控缓解脑疲劳的效果提供了评价手段

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