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-  2018 

姜黄素/聚(α-氰基丙烯酸异丁酯)载药微球的制备及其药物释放

DOI: doi:10.7507/1001-5515.201701045

Keywords: 姜黄素, α-氰基丙烯酸异丁酯, 载药微球, 药物释放

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Abstract:

以 α-氰基丙烯酸异丁酯(iBCA)为原料、泊洛沙姆 188 为乳化剂,以捏合法制得的姜黄素(Cur)/羟丙基-β-环糊精(HP-β-CD)包合物(Cur-HP-β-CD)为负载药物,经一步乳化法制得姜黄素/聚(α-氰基丙烯酸异丁酯)载药微球(Cur-HP-β-CD-PiBCA)。考察乳化剂、负载药物的浓度对微球粒径与分布、微球载药率及包封率的影响,并对载药微球的药物释放进行了研究。结果表明:随着乳化剂浓度从 0.01% 增加到 0.07%,载药微球粒径下降,粒径分布变宽,载药率和包封率均增加,适宜的乳化剂浓度为 0.05%;随着药物浓度从 0.03% 增加到 0.07%,微球载药率升高,包封率下降;载药微球的载药率越高,最终的药物累积释放百分率越低。姜黄素经包合和负载,不仅可以有效改善其亲水性,而且可以提高其溶出度,为提高姜黄素的生物利用度奠定了基础

References

[1]  1. 林琳, 王平, 尹如铁, 等. 姜黄素抗肿瘤机制研究进展. 华西医学, 2009, 24(5): 1320-1322.
[2]  2. 韩刚, 霍文, 李秋影. 姜黄素的稳定性研究. 中成药, 2007, 29(2): 291-293.
[3]  3. 杨鹏波, 张华. 脂质体的研究新进展. 浙江中医药大学学报, 2013, 37(7): 936-939.
[4]  4. 张盛伟, 李湘洲, 李文生, 等. 姜黄素纳米混悬剂的制备及其表征. 林产化学与工业, 2016, 36(2): 109-114.
[5]  5. Liu Jieying, Chen Siyuan, Lv Li, et al. Recent progress in studying curcumin and its nano-preparations for cancer therapy. Curr Pharm Des, 2013, 19(11): 1974-1993.
[6]  6. Duan Jinghua, Zhang Yangde, Han Shiwei, et al. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm, 2010, 400(1/2): 211-220.
[7]  7. Mulik R, Mahadik K, Paradkar A. Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study. Eur J Pharm Sci, 2009, 37(3/4): 395-404.
[8]  8. Hani U, Shivakumar H G, Srivastava A, et al. Design and optimization of curcumin-HPβCD bioadhesive vaginal tablets by 23 factorial design: in vitro and in vivo evaluation. J Pharm Innov, 2015, 10(1): 21-35.
[9]  9. Doppalapudi S, Jain A, Khan W, et al. Biodegradable polymers—an overview. Polym Adv Technol, 2014, 25(5, SI): 427-435.
[10]  10. ?uri? A, Keller B L, Reul R A, et al. Development and lyophilization of itraconazole loaded poly(butyl cyanoacrylate) nanospheres as a drug delivery system. Eur J Pharm Sci, 2015, 78(14): 121-131.
[11]  11. Tian Xinhua, Lin Xiaoning, Wei Feng, et al. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. Int J Nanomedicine, 2011, 6(6): 445-452.
[12]  12. 张强, 廖工铁. 硫酸庆大霉素聚氰基丙烯酸正丁酯毫微球制备工艺研究. 中国药学杂志, 1996, 31(1): 24-27.
[13]  13. Maskarinec S A, Hannig J, Lee R C, et al. Direct observation of poloxamer 188 insertion into lipid monolayers. Biophys J, 2002, 82(3): 1453-1459.
[14]  14. Mitra A, Lin Senshang. Effect of surfactant on fabrication and characterization of paclitaxel-loaded polybutylcyanoacrylate nanoparticulate delivery systems. J Pharm Pharmacol, 2003, 55(7): 895-902.
[15]  15. Illum L, Khan M, Mak E. Evaluation of carrier capacity and release characteristics for poly(butyl 2-cyanoacrylate) nanoparticles. Int J Pharm, 1986, 30(1): 17-28.

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