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-  2015 

干细胞微囊泡在组织损伤修复中的应用前景

DOI: doi:10.7507/1001-5515.20150125

Keywords: 微囊泡, 干细胞, 再生医学, 组织修复

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Abstract:

微囊泡(MVs)是指从细胞表面脱落或分泌的小圆球形膜样结构, 含有母细胞来源脂质、蛋白和遗传物质。近年来, MVs作为细胞间信息传递的新途径正逐渐引起学者们关注。干细胞来源MVs通过细胞内化作用可转移生物活性物质进入靶细胞, 在组织损伤模型中可重编程损伤组织细胞表型, 促进组织再生和修复。其作用机制与MVs富含生物活性脂质、抗凋亡因子、生长因子或细胞因子, 转移mRNA和调控miRNA到损伤组织细胞, 调控靶细胞功能有关。因此, 开发干细胞来源MVs应用于组织再生和修复治疗, 可作为一种安全有效的无细胞治疗策略

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