目的研究纤维蛋白原及血浆D-二聚体含量在不同危险分层急性肺动脉栓塞患者中的差异。 方法回顾分析天津医科大学总医院呼吸科2013年1月至2014年1月收治的急性肺动脉栓塞患者60例。收集患者一般资料, 并按2008年欧洲急性肺动脉栓塞分层标准分为高危组(19例)、中危组(21例)和低危组(20例)。同时随机抽取同期呼吸困难及胸痛的非急性肺动脉栓塞患者14例作为对照组。比较上述各组血浆D-二聚体及纤维蛋白原含量差异。 结果急性肺动脉栓塞患者中, 高危组、中危组和低危组在一般情况上差异无统计学意义( P > 0.05), 但危险分层越高, 纤维蛋白原含量越低( P < 0.05), D-二聚体含量越高( P < 0.05)。对照组患者与急性肺动脉栓塞患者相比, 纤维蛋白原含量更高, D-二聚体含量更低, 差异均有统计学意义( P < 0.05)。血浆纤维蛋白原含量与D-二聚体水平呈负相关(相关系数 r为-0.805)。 结论纤维蛋白原增高是急性肺动脉栓塞发生的高危因素之一, 当急性肺动脉栓塞发生后, 纤维蛋白原含量降低, 纤维蛋白原含量可用于急性肺动脉栓塞诊断及危险程度分级
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