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-  2015 

奥马珠单抗治疗难治性哮喘疗效的Meta分析

DOI: doi:10.7507/1671-6205.2015111

Keywords: 难治性哮喘, 奥马珠单抗, IgE, 抗IgE抗体, Meta分析

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Abstract:

目的系统评价奥马珠单抗对12~75岁难治性哮喘患者的治疗效果及临床应用。 方法计算机检索Pubmed、Web of Science、Embase等数据库, 纳入研究奥马珠单抗辅助治疗过敏性哮喘效果的随机对照试验, 由两位研究者进行资料提取和质量评价后, 采用Review Manage 5.1软件进行Meta分析。 结果共纳入10个随机对照试验。与对照组比较, 奥马珠单抗组能显著降低12~75岁难治性哮喘患者的激素稳定期急性发作率[RR=0.56, 95% CI(0.42, 0.75), P<0.000 1]以及激素减量期急性发作率[RR=0.53, 95% CI(0.48, 0.60), P<0.000 01], 显著减少至少急性恶化发作1次患者的比例[RR=0.71, 95% CI(0.61, 0.84), P<0.000 01], 并显著降低糖皮质激素用量(≥50%)[RR=1.51, 95% CI(1.24, 1.84), P<0.001]。另外, 奥马珠单抗能显著改善哮喘患者生活质量[RR=1.25, 95% CI(1.13, 1.38), P<0.000 01];但对难治性哮喘患者急诊就诊率无显著影响[RR=0.63, 95% CI(0.28, 1.44), P<0.001]。 结论在哮喘指南常规治疗基础上加用奥马珠单抗, 可减少难治性哮喘患者急性发作率并降低糖皮质激素用量, 改善患者生活质量

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