1. ？Orie NGM, Sluiter HJ, de Vries K, et al. The host factor in bronchitis. In:Orie NGM, Sluiter HJ, eds. Bronchitis. Assen, the Netherlands:Royal van Gorcum,1961,43-59.
[2]
2. Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD:what are its features and how important is it? Thorax,2009,64:728-735.
[3]
13. Kitaguchi Y, Komatsu Y, Fujimoto K, et al. Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma. Int J Chron Obstruct Pulmon Dis,2012,7:283-289.
[4]
14. Ravensberg AJ, Slats AM, van Wetering S, et al. CD8+ T cells characterize early smoking-related airway pathology in patients with asthma. Respir Med,2013,107:959-966.
[5]
15. Dima E, Rovina N, Gerassimou C, et al. Pulmonary function tests, sputum induction, and bronchial provocation tests:diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int J Chron Obstruct Pulmon Dis,2010,5:287-296.
[6]
16. Iwamoto H, Gao J, Koskela J, et al. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap. Eur Respir J,2014,43:421-429.
[7]
17. Senhorini A, Ferreira DS, Shiang C, et al. Airway dimensions in fatal asthma and fatal COPD:overlap in older patients. COPD,2013,10:348-356.
[8]
18. Izquierdo-Alonso JL, Rodriguez-Gonzalezmoro JM, de Lucas-Ramos P, et al. Prevalence and characteristics of three clinical phenotypes of chronic obstructive pulmonary disease (COPD). Respir Med,2013,107:724-731.
[9]
19. Martinez FJ, Standiford C, Gay SE. Is it asthma or COPD? The answer determines proper therapy for chronic airflow obstruction. Postgrad Med,2005,117:19-26.
[10]
20. Cazzola M, Rogliani P, Novelli L, et al. Inhaled corticosteroids for chronic obstructive pulmonary disease. Expert Opin Pharmacother,2013,14:2489-2499.
[11]
21. Siva R, Green RH, Brightling CE, et al. Eosinophilic airway inflammation and exacerbations of COPD:a randomised controlled trial. Eur Respir J,2007,29:906-913.
[12]
22. Green RH, Brightling CE, Mckenna S, et al. Asthma exacerbations and sputum eosinophil counts:a randomised controlled trial. Lancet,2002,360:1715-1721.
[13]
24. Miravitlles M, Soriano J B, Ancochea J, et al. Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status. Respir Med,2013,107:1053-1060.
[14]
25. Waschki B, Kirsten A, Holz O, et al. Physical activity is the strongest predictor of all-cause mortality in patients with COPD:a prospective cohort study. Chest,2011,140:331-342.
[15]
27. Fu JJ, Gibson PG, Simpson JL, et al. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration,2014,87:63-74.
[16]
3. Hardin M, Silverman EK, Barr RG, et al. The clinical features of the overlap between COPD and asthma. Respir Res,2011,12:127.
[17]
4. Boulet LP, Lemiere C, Archambault F, et al. Smoking and asthma:clinical and radiologic features, lung function, and airway inflammation. Chest,2006,129:661-668.
[18]
5. Tashkin DP, Celli B, Decramer M, et al. Bronchodilator responsiveness in patients with COPD. Eur Respir J,2008,31:742-750.
[19]
6. Vonk JM, Jongepier H, Panhuysen CI, et al. Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up. Thorax,2003,58:322-327.
[20]
7. Louie S, Zeki AA, Schivo M, et al. The asthma-chronic obstructive pulmonary disease overlap syndrome:pharmacotherapeutic considerations. Expert Rev Clin Pharmacol,2013,6:197-219.
[21]
8. Rhee CK, Yoon HK, Yoo KH, et al. Medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthma. COPD,2014,11:163-170.
[22]
9. Zeki AA, Schivo M, Chan A, et al. The asthma-COPD overlap syndrome:a common clinical problem in the elderly. J Allergy (Cairo),2011,2011:861926.
[23]
10. Soler-Cataluna JJ, Cosio B, Izquierdo JL, et al. Consensus document on the overlap phenotype COPD-asthma in COPD. Arch Bronconeumol,2012,48:331-337.
[24]
11. Neves MC, Neves YC, Mendes CM, et al. Evaluation of atopy in patients with COPD. J Bras Pneumol,2013,39:296-305.
[25]
12. Papi A, Romagnoli M, Baraldo S, et al. Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am J Respir Crit Care Med,2000,162:1773-1777.
[26]
23. Kauppi P, Kupiainen H, Lindqvist A, et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma,2011,48:279-285.
[27]
26. Garcia-Rio F, Rojo B, Casitas R, et al. Prognostic value of the objective measurement of daily physical activity in patients with COPD. Chest,2012,142:338-346.
