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-  2015 

雾化吸入抗生素治疗呼吸机相关性肺炎的临床疗效观察

DOI: doi:10.7507/1671-6205.2015067

Keywords: 呼吸机相关性肺炎, 雾化疗法, 机械通气

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Abstract:

目的评价雾化吸入阿米卡星治疗呼吸机相关性肺炎(VAP)的临床疗效和安全性。 方法选取2010年1月至2013年12月期间复旦大学附属上海市第五人民医院收治的VAP患者120例,随机分为两组:雾化治疗组(雾化组,60例)和常规治疗组(对照组,60例)。在相同常规治疗基础上,由经治医师根据相关指南决定患者全身抗生素的使用,雾化组在此基础上给予阿米卡星400 mg雾化吸入,对照组给予生理盐水5 mL雾化吸入,每日2次,观察两组患者的临床治愈率、细菌清除率、死亡率、脱机率及不良反应。 结果研究第7 d,雾化组患者的临床治愈率大于对照组(75.0%比53.3%,P=0.013),细菌清除率大于对照组(75.0%比44.4%,P=0.008),但两组患者的粗死亡率、脱机率、不良反应比较,差异均无统计学意义。第28 d,雾化组患者的脱机率大于对照组(71.7%比51.7%,P=0.024),但死亡率差异均无统计学意义。 结论雾化吸入阿米卡星治疗VAP,有助于提高患者的临床治愈率、细菌清除率和远期脱机率,无明显不良反应,但未能降低患者的死亡率

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