目的 观察阻塞性睡眠呼吸暂停（OSA）患者–A930G、C242T 基因多态性与认知功能障碍的相关性，探讨由 CYBA 编码的 p22phox 等位基因在合并有认知功能障碍的 OSA 患者中的作用。 方法 选择 2014 年 9 月至 2016 年 11 月于呼吸睡眠科就诊的男性非吸烟 OSA 患者，其中认知功能障碍 OSA 患者 157 例，无认知功能障碍 OSA 患者 526 例。对患者进行认知功能评估、多导睡眠监测及遗传分析，ELISA 法测定还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NOX）活性和尿 8-羟基脱氧鸟苷（8-OH-dG）水平。 结果 –930G 等位基因携带者频率在两组受试者中差异无统计学意义（P>0.05）。无认知功能障碍的 OSA 受试者 TT/CT 基因型频率明显升高（P<0.05）。认知功能障碍的 OSA 受试者 NOX 活性较高（P<0.01），无等位基因 T 突变的受试者具有更高的 NOX 活性（P<0.05）。认知功能障碍的 OSA 受试者尿 8-OH-dG 水平较高（P<0.05），无等位基因 T 变异的受试者尿8-OH-dG 水平更高（P<0.05）。 结论 p22phox C242T 多态性可能参与了 OSA 合并认知功能障碍氧化应激的发生发展
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