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-  2015 

妊娠期糖尿病对肺发育的影响

DOI: doi:10.7507/1671-6205.2015048

Keywords: 妊娠糖尿病, 肺结构发育, 链脲佐菌素, 细胞增殖, 细胞凋亡

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Abstract:

目的建立胎儿宫内高血糖暴露模型,探讨该模型对新生鼠不成熟肺细胞凋亡、增殖及肺结构发育的影响。 方法健康SD妊娠大鼠随机分成高血糖组(STZ组)和正常妊娠组,每组20只。STZ组:妊娠4.5 d腹腔注射1%链脲佐菌素(STZ)溶液40 mg/kg,正常妊娠组则在相同时点相同条件下注射同体积柠檬酸缓冲液。记录腹腔注射STZ前,妊娠6.5 d、11.5 d、16.5 d和20.5 d两组孕鼠尾静脉随机血糖;记录新生鼠出生当天(D0)、第7天(D7)的体质量、存活率;测量新生鼠D0、D7肺质量、肺间隔厚度、辐射状肺泡计数、肺细胞凋亡和增殖情况。 结果注射STZ后,与正常妊娠组相比,STZ组孕鼠各时点随机血糖值显著增高(P<0.05);D0、D7新生鼠存活率降低(P=0.00);D0时新生鼠体质量降低(P<0.05)、相对肺质量降低(P<0.05)、肺间隔变薄(P<0.05),辐射状肺泡计数无明显变化。D0时STZ组肺细胞凋亡指数显著高于正常妊娠组[(11.8±1.1)%比(3.4±0.7)%,P=0.00]。STZ组新生鼠肺细胞增殖在D0、D7均显著增加(P<0.05)。 结论妊娠4.5 d腹腔注射1% STZ溶液40 mg/kg,可成功建立胎鼠宫内高血糖暴露模型。胎鼠高血糖暴露可增加出生当天新生鼠死亡率、肺泡细胞凋亡和增殖,影响肺结构的发育

References

[1]  5. Chappell JJ,Wang X,Loeken M.Diabetes and apoptosis:neural crest cells and neural tube. Apoptosis,2009,14:1472-1483.
[2]  9. Kiss AC, Woodside B, Felício LF, et al.Impact of maternal mild hyperglycemia on maternal care and offspring development and behavior of Wistar rats.Physiol Behav,2012,107:292-300.
[3]  10. Jian Yun X, Zhaoxia L, Yun C, et al. Changes in maternal glucose metabolism after the administration of dexamethasone for fetal lung development. Int J Endocrinol,2012,2012:652806.
[4]  1. ?Yang PX, Li XZ, Xu C, et al. Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.Sci Signal,2013,6:74.
[5]  2. Sukanya S,Bay BH,Tay SS,et al.Frontiers in research on maternal diabetes-induced neural tube defects:past, present and future.World J Diabetes,2012,3:196-200.
[6]  3. Mendoza Martínez Tde J, Morales Morales MP, Jiménez Perea Mde L, et al. Fetal lung maturity delayed on diabetic pregnancies.Ginecol Obstet Mex,2005,73:183-193.
[7]  4. Weindling AM.Offspring of diabetic pregnancy:short-term outcomes.Semin Fetal Neonatal Med,2009,14:111-118.
[8]  6. Jiang B,Kumar SD,Loh WT,et al.Global gene expression analysis of cranial neural tubes in embryos of diabetic mice.J Neurosci Res,2008,86:3481-3493.
[9]  7. G?reskog M,Cederberg J,Eriksson U,et al.Maternal diabetes in vivo and high glucose concentration in vitro increases apoptosis in rat embryos.Reprod Toxicol,2007,23:63-74.
[10]  8. 李鑫,罗淑静,张凯,等.链脲佐菌素诱导孕鼠高血糖子鼠高出生体质量模型的建立及孕鼠高血糖对子鼠远期生长代谢的影响.中华妇产科杂志,2012,47:769-776.

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