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-  2016 

液基细胞学在超声支气管镜引导下经支气管纵隔淋巴结针吸活检术的临床价值研究

DOI: doi:10.7507/1671-6205.2016064

Keywords: 超声支气管镜引导下经支气管纵隔淋巴结针吸活检术, 液基细胞学, 传统细胞学涂片

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Abstract:

目的探讨液基细胞学在超声支气管镜引导下经支气管纵隔淋巴结针吸活检术(EBUS-TBNA)中的诊断价值。 方法前瞻性分析2012年6月至2013年9月四川大学华西医院呼吸与危重症医学科行EBUS-TBNA检查的600例患者。患者在局部麻醉和中度镇静的情况下,行EBUS-TBNA获取病理组织以及细胞学标本。对每例患者的抽吸活检组织均进行薄层液基细胞学检查及传统细胞学涂片。必要时,组织细胞采用免疫组化方法进行分析诊断并与组织学诊断进行比较。 结果组织学检查确诊480例恶性肿瘤以及120例良性病变。SurePath液基细胞学检查术与传统巴氏涂片法敏感性分别为82.1%和56.0%,特异性分别为87.5%和82.5%,阳性预测值分别为96.3%和92.8%,阴性预测值分别为54.9%和31.9%,差异有统计学意义(P < 0.05)。两者联合特异性为100.0%。 结论液基细胞学检测能提升EBUS-TBNA的细胞学检测的诊断价值。细胞学检测结果难以确诊时,需进行组织学检测

References

[1]  2. Ye T, Hu H, Luo X, et al. The role of endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) for qualitative diagnosis of mediastinal and hilar lymphadenopathy: a prospective analysis. BMC Cancer, 2011, 11:100.
[2]  3. Gu P, Zhao YZ, Jiang LY, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. Eur J Cancer, 2009, 45:1389-1396.
[3]  7. Schmid-Bindert G, Wang Y, Jiang H, et al. EBUS-TBNA provides highest RNA yield for multiple biomarker testing from routinely obtained small biopsies in non-small cell lung cancer patients--a comparative study of three different minimal invasive sampling methods. PLoS One, 2013, 8:e77948.
[4]  9. Asano F, Aoe M, Ohsaki Y, et al. Complications associated with endobronchial ultrasound-guided transbronchial needle aspiration: a nationwide survey by the Japan Society for Respiratory Endoscopy. Respir Res, 2013, 14:50.
[5]  11. Norimatsu Y, Kouda H, Kobayashi TK, et al. Utility of thin-layer preparations in the endometrial cytology: evaluation of benign endometrial lesions. Ann Diagn Pathol, 2008, 12:103-111.
[6]  14. Takei H, Ruiz B, Hicks J. Cervicovaginal flora: comparison of conventional pap smears and a liquid-based thin-layer preparation. Am J Clin Pathol, 2006, 125:855-859.
[7]  1. Yasufuku K, Chiyo M, Sekine Y, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes. Chest, 2004, 126:122-128.
[8]  5. Navani N, Lawrence DR, Kolvekar S, et al. Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial. Am J Respir Crit Care Med, 2012, 186:255-260.
[9]  6. Steinfort DP, Liew D, Conron M, et al. Cost-benefit of minimally invasive staging of non-small cell lung cancer: a decision tree sensitivity analysis. J Thorac Oncol, 2010, 5:1564-1570.
[10]  8. Navani N, Brown JM, Nankivell M, et al. Suitability of endobronchial ultrasound-guided transbronchial needle aspiration specimens for subtyping and genotyping of non-small cell lung cancer: a multicenter study of 774 patients. Am J Respir Crit Care Med, 2012, 185:1316-1322.
[11]  12. Hattori M, Kobayashi TK, Nishimura Y, et al. Comparative image analysis of conventional and thin-layer preparations in endometrial cytology. Diagn Cytopathol, 2013, 41:527-532.
[12]  13. Norimatsu Y, Kouda H, Kobayashi TK, et al. Utility of liquid-based cytology in endometrial pathology: diagnosis of endometrial carcinoma. Cytopathology, 2009, 20:395-402.
[13]  18. Delattre C, Fournier C, Bouchindhomme B, et al. Endoscopic ultrasound guided transbronchial fine needle aspiration: a French Department of Pathology's 4-year experience. J Clin Pathol, 2011, 64:1117-1122.
[14]  4. Adams K, Shah PL, Edmonds L, et al. Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis. Thorax, 2009, 64:757-762.
[15]  10. Sakairi Y, Hoshino H, Fujiwara T, et al. Validation of EBUS-TBNA-integrated nodal staging in potentially node positive non-small cell lung cancer. Gen Thorac Cardiovasc Surg, 2013, 61: 522-527.
[16]  15. Norimatsu Y, Yanoh K, Kobayashi TK. The role of liquid-based preparation in the evaluation of endometrial cytology. Acta Cytol, 2013, 57:423-435.
[17]  16. Beccati MD, Buriani C, Pedriali M, et al. Quantitative detection of molecular markers ProEx C (minichromosome maintenance protein 2 and topoisomerase IIa) and MIB-1 in liquid-based cervical squamous cell cytology. Cancer, 2008, 114:196-203.
[18]  17. Natu S, Hoffman J, Siddiqui M, et al. The role of endobronchial ultrasound guided transbronchial needle aspiration cytology in the investigation of mediastinal lymphadenopathy and masses, the North Tees experience. J Clin Pathol, 2010, 63:445-451.

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