全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2015 

慢性阻塞性肺疾病急性加重患者肺动脉与主动脉直径比>1和血浆尿钠肽、C反应蛋白、白细胞介素6的相关性分析

DOI: doi:10.7507/1671-6205.2015063

Keywords: 慢性阻塞性肺疾病, 急性加重, 肺动脉高压, 尿钠肽

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探究在慢性阻塞性肺疾病(简称慢阻肺)急性加重患者中,肺动脉主干直径与主动脉直径比值(PA∶A)>1与血浆尿钠肽(BNP)、C反应蛋白(CRP)、白细胞介素6(IL-6)水平的相关性。 方法纳入2013年8月至2013年12月于华西医院呼吸与危重症医学科住院治疗的慢阻肺急性加重患者95例,根据PA∶A是否>1分为两组:PA∶A>1组和PA∶A≤1组。收集两组患者的基本资料,并检测入院24 h内动脉血气分析、血浆BNP、CRP和IL-6水平。 结果PA∶A>1组患者血浆BNP水平为483~4 582 ng/L,中位数为2 005 ng/L;PA∶A≤1组患者血浆BNP水平为137~1 224 ng/L,中位数为404 ng/L,两组患者的血浆BNP水平比较有显著差异(P<0.01),CRP、IL-6水平差异均无统计学意义。 结论在慢阻肺急性加重患者中,PA∶A>1与BNP水平有相关性,但与CRP、IL-6无相关性

References

[1]  1. ?Murray CJ,Lopez AD.Alternative projections of mortality and disability by cause 1990-2020:Global Burden of Disease Study. Lancet,1997,349:1498-1504.
[2]  3. Iyer AS,Wells JM,Vishin S,et al. CT scan-measured pulmonary artery to aorta ratio and echocardiography for detecting pulmonary hypertension in severe COPD.Chest,2014,145:824-832.
[3]  16. Sims MW,Margolis DJ,Localio AR,et al. Impact of pulmonary artery pressure on exercise function in severe COPD. Chest,2009,136:412-419.
[4]  18. Parola D,Romani S,Petroianni A,et al. Treatment of acute exacerbations with non-invasive ventilation in chronic hypercapnic COPD patients with pulmonary hypertension. Eur Rev Med Pharmacol Sci,2012,16:183-191.
[5]  19. Minai OA,Chaouat A,Adnot S. Pulmonary hypertension in COPD:epidemiology,significance,and management pulmonary vascular disease:the global perspective. Chest,2010,137(6 Suppl):39S-51S.
[6]  20. Hoeper MM,Lee SH,Voswinckel R,et al. Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. J Am Coll Cardiol,2006,48:2546-2552.
[7]  21. Hill NS,Klinger JR,Warburton RR,et al. Brain natriuretic peptide:possible role in the modulation of hypoxic pulmonary hypertension.Am J Physiol,1994,266:308-315.
[8]  22. Inoue Y,Kawayama T,Iwanaga T,et al. High plasma brain natriuretic peptide levels in stable COPD without pulmonary hypertension or cor pulmonale. Intern Med,2009,48:503-512.
[9]  24. 王维,黄志峰,邓穗德.2 型糖尿病患者血清超敏C反应蛋白的表达特性.现代医院,2005,5:20-22.
[10]  25. 赵宇.超敏C反应蛋白在慢性阻塞性肺疾病并发肺动脉高压中的意义.实用医技杂志,2008,15:2761-2763.
[11]  27. Golembeski SM,West J,Tada Y,et al. Interleukin-6 causes mild pulmonary hypertension and augments hypoxia-induced pulmonary hypertension in mice. Chest,2005,128(6 Suppl):572S-573S.
[12]  28. Joppa P,Petrasiva D,Stancak B,et al. Systemic inflammation in patients with COPD and pulmonary hypertension. Chest,2006,130:326-333.
[13]  29. Guignabaert C,Raffestin B,Benferhat R,et al.Serotonin transporter inhibition prevents and reverses monocrotaline induced pulmonary hypertension in rats. Circulation,2005,111:2812-2819.
[14]  5. 王同生,毛毅敏,孙玉霞,等. 白介素-6 和内皮素-1 在慢性阻塞性肺疾病合并肺动脉高压患者中的表达. 实用医学杂志,2012,28:1977-1979.
[15]  6. Chaouat A,Savale L,Chouaid C,et al. Role for interleukin-6 in COPD-related pulmonary hypertension. Chest,2009,136:678-687.
[16]  8. 荆志成. 2010 年中国肺高血压诊治指南.中国医学前沿杂志 (电子版),2011,3:62-81.
[17]  9. Wells JM,Washko GR,Han MK,et al. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med,2012,367:913-921.
[18]  15. Jensen HH,Godtfredsen NS,Lange P,et al. Potential misclassification of causes of death from COPD. Eur Respir J,2006,28:781-785.
[19]  17. Kessler R,Faller M,Fourgaut G,et al. Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med,1999,159:158-164.
[20]  23. Sormunen P,Kallio MJ,Kili IT,et al.C-reactive protein is useful in distinguishing Gram stain negative bacterial meningitis from viral meningitis in children.Pediater,1999,134:725-729.
[21]  26. Humbert M,Monti G,Brenot F,et al.Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.Am J Respir Crit Care,1995,151:1628-1631.
[22]  2. Ng CS,Wells AU,Padley SP. A CT sign of chronic pulmonary arterial hypertension:the ratio of main pulmonary artery to aortic diameter. J Thorac Imaging,1999,14:270-278.
[23]  4. 高新海,徐仲卿,赵文穗. 血浆氨基末端脑钠肽水平与不同程度慢性阻塞性肺疾病肺动脉高压的相关性. 广东医学,2011,32:1150-1151.
[24]  7. MacIntyre N,Huang YC. Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease. Proc Am Thorac Soc,2008,5:530-535.
[25]  10. 刘鹏,郭顺林,雷军强,等. 慢性阻塞性肺疾病相关肺动脉高压的多层螺旋CT评价. 中华结核和呼吸杂志,2012,35:264-268.
[26]  11. 高靳,余建群,白红利,等. 慢性阻塞性肺部疾病病程与肺动脉直径变化关系的多层螺旋CT评价. 实用放射学杂志,2009,25:332-337.
[27]  12. Committee GS. Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease (updated 2013). www.goldcopd.org.
[28]  13. Buist AS,McBurnie MA,Vollmer WM,et al. International variation in the prevalence of COPD (the BOLD Study):a population-based prevalence study.Lancet,2007,370:741-750.
[29]  14. Zhong N,Wang C,Yao W,et al. Prevalence of chronic obstructive pulmonary disease in China:a large,population-based survey. Am J Respir Crit Care Med,2007,176:753-760.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133