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-  2016 

痰培养联合曲霉血清学GM试验对诊断侵袭性曲霉感染的临床价值研究

DOI: doi:10.7507/1671-6205.2016138

Keywords: 半乳甘露聚糖, 痰培养, 曲霉

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Abstract:

目的评价痰培养联合曲霉血清学半乳甘露聚糖(GM)试验对侵袭性曲霉感染的临床诊断价值。 方法对济宁医学院附属医院2012年7月至2013年7月间疑似曲霉感染的216例住院患者进行痰培养和血清ELISA检测。以临床诊断为标准, 评估痰培养和GM试验及联合检测的敏感性、特异性、阳性预测值和阴性预测值, 采用 χ 2检验进行比较。应用受试者工作特征曲线(ROC曲线)比较不同检测的疾病识别能力。 结果痰培养的敏感性和特异性为60.4%和69.9%, GM试验为94.3%和94.5%, 二者联合检测可将诊断的敏感性和特异性分别提高至98.1%和99.4%。联合检测的ROC曲线下面积(AUC)为0.960, 95%可信区间为0.929~0.992。 结论痰真菌培养联合血清GM抗原检测能大幅提高曲霉感染病例的临床诊断效率

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