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-  2015 

涎液化糖链蛋白6在特发性肺纤维化患者支气管肺泡灌洗液和血清中的表达及临床意义

DOI: doi:10.7507/1671-6205.2015058

Keywords: 特发性肺纤维化, 支气管肺泡灌洗液, 涎液化糖链蛋白6

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Abstract:

目的检测涎液化糖链蛋白6(KL-6)在特发性肺纤维化(IPF)患者支气管肺泡灌洗液(BALF)和血清中的表达水平,探讨其临床意义。 方法选取IPF患者34例,Ⅰ期结节病(SAR)患者10例, 用酶联免疫吸附法(ELISA)测定KL-6在BALF及血清中的水平。 结果IPF组患者的用力肺活量(FVC)占预计值百分比(FVC% pred)显著低于SAR组[(69.51±13.65)%比(82.06±5.84)%,P<0.01],一氧化碳弥散量(DLCO)占预计值百分比(DLCO% pred)显著低于SAR组[(48.58±12.73)%比(81.47±6.39)%,P<0.01]。IPF组患者BALF中中性粒细胞百分比高于SAR组[(8.91±6.79)%比(5.50±3.60)%,P<0.05],SAR组淋巴细胞百分比和CD4/CD8高于IPF组[(23.30±12.68)%比(11.71±6.64)%,P<0.05;(4.01±5.10)比(1.46±0.83),P<0.05]。IPF组患者BALF和血清中KL-6浓度高于SAR组[(437.43±251.70) U/mL比(221.59±127.41) U/mL,P<0.05;(857.81±515.53) U/mL比(338.67±168.13) U/mL,P<0.001]。血清KL-6水平与FVC和DLCO明显相关(r=-0.46,r=-0.58)。 结论IPF患者BALF和血清中KL-6水平均增高,血清KL-6水平与FVC和DLCO相关,KL-6有可能作为一项提示IPF临床诊断和严重程度的指标

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