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-  2017 

阻塞性睡眠呼吸暂停低通气综合征血栓前状态危险因素分析

DOI: doi:10.7507/1671-6205.201609043

Keywords: 阻塞性睡眠呼吸暂停低通气综合征, 血栓前状态, 睡眠呼吸暂停低通气指数, 白细胞介素-6, 慢性阻塞性肺疾病

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Abstract:

目的 分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)血栓前状态的危险因素,为 OSAHS 患者静脉血栓栓塞症的预防提供参考和借鉴。 方法 选取 2014 年 6 月至 2016 年 7 月在新疆医科大学附属第一医院经多导睡眠监测(PSG)明确诊断为 OSHAS 并进行了凝血、血栓与纤溶检测及炎症因子组合测定,同时排除存在其他可能影响凝血功能因素的患者共 238 例。其中符合血栓前状态参考标准的患者 56 例(即血栓前状态组),剩余 182 例患者凝血及血栓与纤溶检测不满足参考标准,从中随机抽取 59 例患者为对照组(即非血栓前状态组)。比较两组患者年龄、性别、体重指数(BMI)、睡眠呼吸暂停低通气指数(AHI)、白细胞介素-6(IL-6)、合并慢性阻塞性肺疾病(简称慢阻肺)和合并高血压的状况。 结果 非条件 Logistic 回归分析显示 OSAHS 血栓前状态的危险因素有年龄( OR=1.202,95% CI:1.107~1.305)、IL-6( OR=1.127,95% CI:1.014~1.252)、AHI( OR=1.151,95% CI:1.055~1.256)、合并慢阻肺( OR=4.749,95% CI:1.046~21.555)。 结论 年龄、AHI、IL-6、合并慢阻肺可能是 OSAHS 患者血栓前状态的危险因素,其中合并慢阻肺可能是最重要的危险因素

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