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-  2016 

非小细胞肺癌患者中外周血浆K-ras基因突变的研究

DOI: doi:10.7507/1671-6205.2016107

Keywords: 非小细胞肺癌, 外周血, K-ras基因突变

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Abstract:

目的比较四川地区非小细胞肺癌患者外周血浆游离DNA与肺癌组织K-ras基因突变的一致性,探讨外周血K-ras检测的临床价值。 方法应用突变富集液相芯片检测技术比较242例非小细胞肺癌患者的肺癌组织、外周血浆游离DNA中的K-ras基因突变检出率,观察血浆检测与组织检测的一致性。 结果在本组242例非小细胞肺癌病例中,肺癌组织中检测出K-ras基因突变者共有12例患者,检出率为4.96%,外周血浆中检出10例K-ras基因突变,检出率为4.13%。外周血浆游离DNA中的K-ras基因突变检出率与肺癌组织中的检出率具有较好的一致性(Kappa值=0.81)。 结论非小细胞肺癌患者外周血浆游离DNA中的K-ras可替代肺癌组织进行K-ras基因突变的筛查

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