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-  2017 

CYP1A1 rs4646903 基因多态性与慢性阻塞性肺疾病易感性的 Meta 分析

DOI: doi:10.7507/1671-6205.201611041

Keywords: 慢性阻塞性肺疾病, 细胞色素氧化酶 P450, CYP1A1, 基因多态性, Meta 分析

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Abstract:

目的 分析细胞色素氧化酶 P450(CYP)酶系中 CYP1A1 rs4646903 基因多态性与慢性阻塞性肺疾病(简称慢阻肺)易感性的关联强度。 方法 检索 CNKI 数据库、VIP 数据库、WanFang 数据库、PubMed 数据库、Cochrane 图书馆及 Embase 数据库,检索时限从建库开始至 2016 年 1 月。查找 CYP1A1 rs4646903 基因多态性与慢阻肺易感性相关的病例对照研究。采用 StataSE 12.0 进行数据分析。应用比值比(OR)及其 95% 可信区间(95%CI)表示其关联强度。 结果 共纳入病例对照研究 6 项,涉及患者 1 050 例,健康对照 1 202 例。Meta 分析结果显示:累加遗传模型(CC vs. TT,OR=1.63,95%CI 1.17~2.27,P=0.004)、隐性遗传模型(CC vs. TC+TT,OR=1.62,95%CI 1.19~2.20,P=0.002)可能是慢阻肺的遗传易感因素。而等位基因模型(C vs. T,OR=1.20,95%CI 0.95~1.51,P=0.118)、显性遗传模型(CC+TC vs. TT,OR=1.19,95%CI 0.82~1.72,P=0.366)可能不会增加慢阻肺的罹患风险。 结论 CYP1A1 rs4646903 基因多态性与慢阻肺易感性相关,且为慢阻肺的危险因素,但还需更多大样本的研究进一步证实

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