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-  2018 

肺黏液表皮样癌一例并文献复习

DOI: doi:10.7507/1671-6205.201805043

Keywords: 肺肿瘤, 黏液表皮样癌, 临床特征, 治疗, 预后

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Abstract:

目的总结肺黏液表皮样癌(PMEC)的临床特征,以提高对该病的诊治水平。 方法对 1 例 PMEC 患者的发病过程、临床表现、胸部影像学特点、病理特征及诊治经过进行回顾性分析。以“pulmonary”或“lung”和“mucoepidermoid carcinoma”为检索词在 PubMed 数据库进行检索,以“肺黏液表皮样癌”为检索词在中国知网数据库和万方数据库中进行检索,检索时间为 2013~2018 年,复习相关文献。 结果患者女性,21 岁,因咳嗽、咳痰 5 个月余,咯血 3 个月余,发热 4 d 于 2017 年 3 月就诊。诊断为 PMEC(低级别)。入院后接受抗感染、纤维支气管镜吸痰、肺泡灌洗等治疗。住院期间患者抗感染效果欠佳,胸部 CT 检查提示右肺中叶占位性病变,经手术切除右全肺后逐渐好转。检索文献报道 13 例,患者无明显性别差异,中位年龄 40 岁(绝大多数小于 50 岁);临床表现多为咳嗽、发热、咯血,常伴有肺不张。大部分患者经手术切除后可好转,少数需接受包括放疗、化疗、靶向治疗等在内的综合治疗。 结论PMEC 临床少见,目前病因尚未明确,病理以低级别为主,大部分患者经手术切除后可治愈

References

[1]  1. 吴一龙, 程颖, 周清, 等. 中国临床肿瘤学会(CSCO)原发性肺癌诊疗指南. 北京: 人民卫生出版社, 2017, 87-88.
[2]  2. Qian X, Sun Z, Pan W, et al. Childhood bronchial mucoepidermoid tumors: a case report and literature review. Oncol Lett, 2013, 6(5): 1409-1412.
[3]  3. 于琳, 堂吉斯. 肺粘液表皮样癌 1 例. 临床肺科杂志, 2017, 22(9): 1741-1743.
[4]  4. Li X, Guo Z, Liu J, et al. Clinicopathological characteristics and molecular analysis of primary pulmonary mucoepidermoid carcinoma: case report and literature review. Thoracic Cancer, 2017, 9(2): 316-323.
[5]  5. Omesh T, Gupta R, Saqi A, et al . A rare case of endobronchial mucoepidermoid carcinoma of the lung presenting as non-resolving pneumonia. Respir Med Case Rep, 2018, 25: 154-157.
[6]  6. Al-Halawani M, Abdeen Y. Mucoepidermoid carcinoma of the trachea. Quant Imaging Med Surg, 2018, 8(2): 259-260.
[7]  7. Horst M, Dekker M, Braak S. Mucoepidermoid carcinoma of the airways in a young adult male. J Radiol Case Rep, 2017, 11(2): 8-15.
[8]  8. Franco I, Tente D, Coutinho D, et al. Single symptomatic colonic metastasis as first presentation of a pulmonary mucoepidermoid carcinoma. Clin Respir J, 2016, 10(4): 524-529.
[9]  9. 王梦歌, 欧阳松云, 孙培宗, 等. 低度恶性肺粘液表皮样癌并转移一例报告并文献复习. 中国呼吸与危重监护杂志, 2014, 13(4): 409-411.
[10]  10. 裴翀, 王丽娜, 查显奎. 成人支气管黏液表皮样癌 1 例. 临床肺科杂志, 2017, 22(10): 1926-1927.
[11]  11. 李红林, 方进, 邓达标, 等. 支气管黏液表皮样癌 1 例. 中国医学影像技术, 2016, 32(9): 1469.
[12]  12. Li SM, Zhang Z, Tang H, et al. Pathological complete response to gefitinib in a 10-year-old boy with EGFR-negative pulmonary mucoepidermoid carcinoma: a case report and literature review. Clin Respir J, 2017, 11(3): 346-351.
[13]  13. Fink DD, Lomas AM, Roden AC, et al. Primary mucoepidermoid carcinoma of the lung with prominent clear cells. Proc (Bayl Univ Med Cent), 2017, 30(3): 322-324.
[14]  14. Alsidawi S, Morris JC, Wikenheiser-Brokamp KA, et al. Mucoepidermoid carcinoma of the lung: a case report and literature review. Case Rep Oncol Med, 2013: 625243.
[15]  15. 杨朝晖, 王建军, 何燕, 等. 肺原发性黏液表皮样癌的临床病理研究. 肿瘤学杂志, 2015, 21(8): 640-644.
[16]  16. Hayashi I, Muto Y, Fujii Y, et al. Mucoepidermoid carcinoma of the stomach. J Surg Oncol, 1987, 34(2): 94-99.
[17]  17. Choi D, Kim H, Lee KS, et al. Mucoepidermoid carcinoma of the liver diagnosed as a liver abscess: report of a case. Surg Today, 2004, 34(11): 968-972.
[18]  18. Han F, Jiang H, Zhang S. Mucoepidermoid carcinoma of the transverse colon: a rare tumor entity with literature review. Pathol Int, 2017, 67(7): 361-364.
[19]  19. Jiang L, Li P, Xiao Z, et al. Prognostic factors of primary pulmonary mucoepidermoid carcinoma: a clinical and pathological analysis of 34 cases. Int J Clin Exp Pathol, 2014, 7(10): 6792-6799.
[20]  20. Hsieh CC, Sun YH, Lin SW, et al. Surgical outcomes of pulmonary mucoepidermoid carcinoma: a review of 41 cases. PLoS One, 2017, 12(5): e0176918.
[21]  21. Wang YQ, Mo YX, Li S, et al. Low-grade and high-grade mucoepidermoid carcinoma of the lung: CT findings and clinical features of 17 cases. Am J Roentgenol, 2015, 205(6): 1160-1166.
[22]  22. 王辉, 初向阳, 张连斌, 等. 23 例原发性肺黏液表皮样癌外科诊疗及预后分析. 解放军医学院学报, 2015, 36(6): 586-589.
[23]  23. 陈辉, 余建群, 徐忠孜, 等. 原发性肺粘液表皮样癌的多排螺旋 CT 表现与病理对照研究. 临床放射学杂志, 2014, 33(5): 702-706.
[24]  24. 江森, 朱晓华, 孙希文, 等. 气管支气管树黏液表皮样癌的 CT 表现. 中华放射医学杂志, 2010, 44(1): 20-23.
[25]  25. 侯晶晶, 王慧娟, 张国伟, 等. 29 例肺粘液表皮样癌的临床分析. 中国肺癌杂志, 2017, 20(3): 168-174.
[26]  26. 黄焰, 武春燕, 吴伟, 等. 肺原发黏液表皮样癌的临床病理特点及其表皮生长因子受体基因突变情况. 中华病理学杂志, 2016, 45(9): 612-616.
[27]  27. 刘彤华. 诊断病理学. 北京: 人民卫生出版社, 2013, 164-165.
[28]  28. 师晨阳, 李文才, 李彦鹏, 等. 原发性肺黏液表皮样癌 64 例临床病理分析. 郑州大学学报(医学版), 2017, 52(1): 92-95.
[29]  29. Huo Z, Wu H, Li J, et al. Primary pulmonary mucoepidermoid carcinoma: histopathological and moleculargenetic studies of 26 cases. PLoS One, 2015, 10(11): e0143169.
[30]  30. Yamatani C, Abe M, Shimoji M, et al. Pulmonary adenosquamous carcinoma with mucoepidermoid carcinoma-like component with characteristic p63 staining pattern: either a novel subtype originating from bronchial epithelium or variant mucoepidermoid carcinoma. Lung Cancer, 2014, 84(1): 45-50.
[31]  31. Clauditz TS, Gontarewicz A, Wang CJ, et al. 11q21 rearrangement is a frequent and highly specific genetic alteration in mucoepidermoid carcinoma. Diagn Mol Pathol, 2012, 21(3): 134-137.
[32]  32. 黄丙连, 刘玮, 赖国祥. 肺粘液表皮样癌的临床特征及预后影响因素分析. 中国临床实用医学, 2016, 7(5): 12-16.
[33]  33. Tamaki T, Tanijiri T, Katashiba Y, et al. A case of lung mucoepidermoid carcinoma with EGFR mutation successfully treated by gefitinib. Haigan, 2010, 50(1): 27-32.
[34]  34. Xi JJ, Jiang W, Lu SH, et al. Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases. World J Surg Oncol, 2012, 10: 232.
[35]  35. Seethala RR, Dacic S, Cieply K, et al. A reappraisal of the MECT1 /MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol, 2010, 34(8): 1106-1121.
[36]  36. 聂玲, 张孟尼, 龚静, 等. MECT1-MAML2 融合基因在肺黏液表皮样癌诊断中的应用. 诊断病理学杂志, 2017, 24(4): 296-298.

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