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-  2016 

抗生素治疗呼吸机相关性气管支气管炎疗效的Meta分析

DOI: doi:10.7507/1671-6205.2016080

Keywords: 呼吸机相关性气管支气管炎, 呼吸机相关性肺炎, 抗生素, Meta分析

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Abstract:

目的 系统评价抗生素治疗呼吸机相关性气管支气管炎(VAT)的疗效。 方法 对Pubmed、Web of Science、OVID(ACP Journal Club、Cochrane临床试验中心数据库、Embase和Medline)、CNKI、VIP、万方数据库等数据库进行抗生素治疗VAT相关的文献检索,检索截止时间为2016年3月。采用RevMan 5.3软件对数据进行Meta分析。 结果 共纳入6篇研究,包括769例患者,其中使用抗生素治疗组患者为432例,未使用抗生素治疗组患者为337例。Meta分析结果显示,两组间呼吸机相关性肺炎(VAP)发生率[OR=0.27,95%CI(0.17,0.43),P＜0.05]、ICU住院时间[MD-1.51,95%CI(-2.04,-0.98),P＜0.000 01]差异具有统计学意义,但机械通气时间[MD-2.52,95%CI(-6.85,1.81),P=0.25]、死亡率[OR=0.41,95%CI(0.15,1.14),P=0.09]和耐药菌产生情况[OR=0.62,95%CI(0.17,2.19),P＞0.05]差异无统计学意义。 结论 VAT患者使用抗生素治疗能显著降低VAP的发生率,但Meta分析结果仍需更多高质量随机对照试验进行验证

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