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-  2017 

细胞自噬在周围神经损伤及再生中研究进展

DOI: doi:10.7507/1002-1892.201611136

Keywords: 细胞自噬, 雪旺细胞, 周围神经, 修复重建

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Abstract:

目的 总结细胞自噬在周围神经损伤后病理生理变化过程中的作用及调控机制,为周围神经损伤的治疗提供新的思路。 方法 广泛查阅近 5 年与细胞自噬在周围神经损伤及再生方面的相关文献,并进行总结与讨论。 结果 通过对小鼠进行药物干预及基因敲除等方法调节其自噬功能后证实,雪旺细胞自噬主要通过 JNK/c-Jun 通路影响后续的髓鞘崩解、炎性细胞浸润及轴突再生等一系列过程,通过调节雪旺细胞自噬可以改变周围神经损伤后瓦勒变性的发生、发展,维持周围神经结构的完整性,但其对后续轴突再生的作用仍存在争议。 结论 细胞自噬过程在周围神经损伤后病理生理变化过程中起着重要的调节作用,深化研究其机制及作用,可为周围神经损伤后治疗方法的研究提供新思路

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