全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2015 

生物因子控释技术在软骨修复领域的研究进展

DOI: doi:10.7507/1002-1892.20150220

Keywords: 生物因子, 控释技术, 软骨修复

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的对近年生物因子控释技术在软骨修复领域的研究进展作一综述。 方法广泛查阅近年有关生物因子控释技术在软骨修复领域的国内外文献并进行综述。 结果目前有多种生物因子用于软骨修复领域,为达到更佳软骨修复效果,可将其与可降解生物材料支架结合,或通过微粒与纳米粒等多种方式实现控释。同时,研究多种生物因子的控释系统和序贯释放技术也是必然选择。 结论尽管目前仍面临许多未解决的问题,软骨修复生物因子的控释技术具有可控性和精细化等特点,已成为关节软骨修复领域研究热点

References

[1]  1. Nukavarapu SP,Dorcemus DL.Osteochondral tissue engineering:Current strategies and challenges.Biotechnol,2013,31(5):706-721.
[2]  17. Choi DH,Park CH,Kim IH,et al.Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system.J Control Release,2010,147(2):193-201.
[3]  18. Re'em T,Kaminer-Israeli Y,Ruvinov E,et al.Chondrogenesis of hMSC in affinity-bound TGF-beta scaffolds.Biomaterials,2012,33(3):751-761.
[4]  30. Jaklenec A,Hinckfuss A,Bilgen B,et al.Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microspherebased scaffolds.Biomaterials,2008,29(10):1518-1525.
[5]  5. Murphy MK,Huey DJ,Hu JC,et al.TGF-β1,GDF-5,and BMP-2 stimulation induces chondrogenesis in expanded human articular chondrocytes and marrow-derived stromal cells.Stem Cells,2015,33(3):762-773.
[6]  6. Johnstone B,Alini M,Cucchiarini M,et al.Tissue engineering for articular cartilage repair-the state of the art.Eur Cell Mater,2013,25:248-267.
[7]  12. Emans PJ,van Rhijn LW,Welting TJ,et al.Autologous engineering of cartilage.Proc Natl Acad Sci U S A,2010,107(8):3418-3423.
[8]  13. Matsumoto T,Cooper GM,Gharaibeh B,et al.Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.Arthritis Rheum,2009,60(5):1390-1405.
[9]  14. Krüger JP,Freymannx U,Vetterlein S,et al.Bioactive factors in platelet-rich plasma obtained by apheresis.Transfus Med Hemother,2013,40(6):432-440.
[10]  15. Sundman EA,Cole BJ,Karas V,et al.The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis.Am J Sports Med,2014,42(1):35-41.
[11]  16. Zhu Y,Yuan M,Meng HY,et al.Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis:a review.Osteoarthritis Cartilage,2013,21(11):1627-1637.
[12]  2. Elmorsy S,Funakoshi T,Sasazawa F,et al.Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.Osteoarthritis Cartilage,2014,22(1):121-127.
[13]  3. Santo VE,Gomes ME,Mano JF,et al.Controlled release strategies for bone,cartilage,and osteochondral engineering-part I:recapitulation of native tissue healing and variables for the design of delivery systems.Tissue Eng B Rev,2013,19(3):308-326.
[14]  4. Jeong CG,Zhang H,Hollister SJ.Three-dimensional polycaprolactone scaffold-conjugated bone morphogenetic protein-2 promotes cartilage regeneration from primary chondrocytes in vitro and in vivo without accelerated endochondral ossification.J Biomed Mater Res A,2012,100(8):2088-2096.
[15]  7. Horbelt D,Denkis A,Knaus P.A portrait of Transforming Growth Factor beta superfamily signalling:background matters.Int J Biochem Cell Biol,2012,44(3):469-474.
[16]  8. Chubinskaya S,Otten L,Soeder S,et al.Regulation of chondrocyte gene expression by osteogenic protein-1.Arthritis Res Ther,2011,13(2):R55.
[17]  9. Dani?ovi? L,Varga I,Polák S.Growth factors and chondrogenic differentiation of mesenchymal stem cells.Tissue Cell,2012,44(2):69-73.
[18]  10. Toh WS,Spector M,Lee EH,et al.Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage.Mol Pharm,2011,8(4):994-1001.
[19]  11. Jeng L,Olsen BR,Spector M.Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels.Acta Biomater,2012,8(6):2203-2212.
[20]  19. Fan H,Tao H,Wu Y,et al.TGF-β3 immobilized PLGA-gelatin/chondroitin sulfate/hyaluronic acid hybrid scaffold for cartilage regeneration.J Biomed Mater Res,2010,95(4):982-992.
[21]  20. Yang HS,La WG,Bhang SH,et al.Hyaline cartilage regeneration by combined therapy of microfracture and long-term bone morphogenetic protein-2 delivery.Tissue Eng Part A,2011,17(13-14):1809-1818.
[22]  21. Griffin DR,Schlosser JL,Lam SF,et al.Synthesis of photodegradable macromers for conjugation and release of bioactive molecules.Biomacromolecules,2013,14(4):1199-1207.
[23]  22. Li X,Wang J,Su G,et al.Spatiotemporal control over growth factor delivery from collagen-based membrane.J Biomed Mater Res A,2012,100(2):396-405.
[24]  23. Richardson TP,Peters MC,Ennett AB,et al.Polymeric system for dual growth factor delivery.Nat Biotechnol,2001,19(11):1029-1034.
[25]  24. Jiang T,Petersen RR,Call G,et al.Development of chondroitin ulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis.J Biomed Mater Res B Appl Biomater,2011,97(2):355-363.
[26]  25. Westhaus E,Messersmith PB.Triggered release of calcium from lipid vesicles:a bioinspired strategy for rapid gelation of polysaccharide and protein hydrogels.Biomaterials,2001,22(5):453-462.
[27]  26. Santo VE,Gomes ME,Mano JF,et al.From nano-to macro-scale:nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering.Nanomedicine (Lond),2012,7(7):1045-1066.
[28]  28. Bian L,Zhai DY,Tous E,et al.Enhanced MSC chondrogenesis following delivery of GF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo.Biomaterials,2011,32(27):6425-6434.
[29]  29. Lim SM,Oh SH,Lee HH,et al.Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering.J Mater Sci Mater Med,2010,21(9):2593-2600.
[30]  31. Lakshmanan A,Zhang S,Hauser CA.Short self-assembling peptides as building blocks for modern nanodevices.Trends Biotechnol,2012,30(3):155-165.
[31]  32. Kopesky PW,Vanderploeg EJ,Kisiday JD,et al.Controlled delivery of transforming growth factor beta1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling.Tissue Eng Part A,2011,17(1-2):83-92.
[32]  27. Dormer NH,Singh M,Zhao L,et al.Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals.J Biomed Mater Res A,2012,100(1):162-170.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133