17. Lim JY, Yi T, Choi JS,et al. Intraglandular transplantation of bone marrow-derived clonal mesenchymal stem cells for amelioration of post-irradiation salivary gland damage. Oral Oncol, 2013, 49(2): 136-143.
[2]
21. Hai B, Yang Z, Shangguan L,et al. Concurrent transient activation of Wnt/beta-catenin pathway prevents radiation damage to salivary glands. Int J Radiat Oncol Biol Phys, 2012, 83(1): e109-116.
[3]
22. Garcia-Gallastegui P, Ibarretxe G, GarciaRamirez JJ,et al. DLK1 regulates branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling. Biol Cell, 2014, 106(8): 237-253.
[4]
28. Beauchamp P, Mortitz W, Kelm JM,et al. Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Tissue Eng Part C Methods, 2015, 21(8): 852-861.
[5]
29. Ono H, Obana A, Usami Y,et al. Regenerating salivary glands in the microenvironment of induced pluripotent stem cells. Biomed Res Int, 2015, 2015: 293570.
[6]
35. Okumura K, Shinohara M, Endo F. Capability of tissue stem cells to organize into salivary rudiments. Stem Cells Int, 2012, 2012: 502136.
[7]
36. Sneddon JB, Borowiak M, Melton DA. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012, 491(7426): 765-768.
[8]
38. Cantara SI, Soscia DA, Sequeira SJ,et al. Selective functionalization of nanofiber scaffolds to regulate salivary gland epithelial cell proliferation and polarity. Biomaterials, 2012, 33(33): 8372-8382.
[9]
41. Maria OM, Maria O, Liu Y,et al. Matrigel improves functional properties of human submandibular salivary gland cell line. Int J Biochem Cell Biol, 2011, 43(4): 622-631.
26. Hill G, Headon D, Harris ZI,et al. Pharmacological activation of the EDA/EDAR signaling pathway restores salivary gland function following radiation-induced damage. PLoS One, 2014, 9(11): e112840.
[14]
27. Kawakami M, Ishikawa H, Tachibana T,et al. Functional transplantation of salivary gland cells differentiated from mouse early ES cellsin vitro. Hum Cell, 2013, 26(2): 80-90.
[15]
30. Eiraku M, Watanabe K, Matsuo-Takasaki M,et al. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell, 2008, 3(5): 519-532.
[16]
31. Lancaster MA, Knoblich JA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science, 2014, 345(6194): 1247125.
[17]
34. Jang SI, Ong HL, Gallo A,et al. Establishment of functional acinar-like cultures from human salivary glands. J Dent Res, 2015, 94(2): 304-311.
[18]
37. Skardal A, Smith L, Bharadwaj S,et al. Tissue specific synthetic ECM hydrogels for 3Din vitro maintenance of hepatocyte function. Biomaterials, 2012, 33(18): 4565-4575.
[19]
40. Yang TL, Hsiao YC. Chitosan facilitates structure formation of the salivary gland by regulating the basement membrane components. Biomaterials, 2015, 66: 29-40.
[20]
3. Li Y, Taylor JM, Ten Haken RK,et al. The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy. Int J Radiat Oncol Biol Phys, 2007, 67(3): 660-669.
[21]
4. Lombaert IM, Brunsting JF, Wierenga PK,et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One, 2008, 3(4): e2063.
[22]
5. Feng J, van der Zwaag M, Stokman MA,et al. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiother Oncol, 2009, 92(3): 466-471.
[23]
6. Gorjup E, Danner S, Rotter N,et al. Glandular tissue from human pancreas and salivary gland yields similar stem cell populations. Eur J Cell Biol, 2009, 88(7): 409-421.
[24]
1. Pringle S, Van Os R, Coppes RP. Adult salivary gland stem cells and a potential therapyfor xerostomia. Stem Cells, 2013, 31(4): 613-619.
[25]
2. Vissink A, van Luijk P, Langendijk JA,et al. Current ideas to reduce or salvage radiation damage to salivary glands. Oral Dis, 2015, 21(1): e1-10.
[26]
7. Lombaert IM, Brunsting JF, Wierenga PK,et al. Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool. Stem Cells, 2008, 26(10): 2595-2601.
[27]
8. Tatsuishi Y, Hirota M, Kishi T,et al. Human salivary gland stem/progenitor cells remain dormant even after irradiation. Int J Mol Med, 2009, 24(3): 361-366.
[28]
9. van Luijk P, Pringle S, Deasy JO,et al. Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer. Sci Transl Med, 2015, 7(305): 305ra147.
[29]
10. Nanduri LS, Lombaert IM, van der Zwaag M,et al. Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiother Oncol, 2013, 108(3): 458-463.
[30]
11. Xiao N, Lin Y, Cao H,et al. Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest, 2014, 124(8): 3364-3377.
[31]
12. Coppes RP, Stokman MA. Stem cells and the repair of radiation-induced salivary gland damage. Oral Dis, 2011, 17(2): 143-153.
[32]
13. Nanduri LS, Maimets M, Pringle SA,et al. Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiother Oncol, 2011, 99(3): 367-372.
[33]
14. Lu L, Li Y, Du MJ,et al. Characterization of a Self-renewing and Multi-potent Cell Population Isolated from Human Minor Salivary Glands. Sci Rep, 2015, 5: 10106.
[34]
15. Banh A, Xiao N, Cao H,et al. A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichmentin vivo. Clin Cancer Res, 2011, 17(23): 7265-7272.
[35]
16. Neumann Y, David R, Stiubea-Cohen R,et al. Long-term cryopreservation model of rat salivary gland stem cells for future therapy in irradiated head and neck cancer patients. Tissue Eng Part C Methods, 2012, 18(9): 710-718.
[36]
18. Zhang NN, Huang GL, Han QB,et al. Functional regeneration of irradiated salivary glands with human amniotic epithelial cells transplantation. Int J Clin Exp Pathol, 2013, 6(10): 2039-2347.
[37]
19. Tran SD, Liu Y, Xia D,et al. Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation. PLoS One, 2013, 8(4): e61632.
[38]
20. Zheng C, Cotrim AP, Rowzee A,et al. Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands. Clin Cancer Res, 2011, 17(9): 2842-2851.
[39]
23. Hai B, Qin L, Yang Z,et al. Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation. Clin Cancer Res, 2014, 20(1): 140-150.
[40]
24. Kojima T, Kanemaru S, Hirano S,et al. The protective ef？cacy of basic ？broblast growth factor in radiation-induced salivary gland dysfunction in mice. Laryngoscope, 2011, 121(9): 1870-1875.
[41]
25. Marmary Y, Adar R, Gaska S,et al. Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL6 modulation. Cancer Res, 2016, 76(5): 1170-1180.
33. Rookmaaker MB, Schutgens F, Verhaar MC,et al. Development and application of human adult stem or progenitor cell organoids. Nat Rev Nephrol, 2015, 11(9): 546-554.
[44]
39. Pradhan S, Liu C, Zhang C,et al. Lumen formation in three-dimensional cultures of salivary acinar cells. Otolaryngol Head Neck Surg, 2010, 142(2): 191-195.
[45]
44. Peters SB, Naim N, Nelson DA,et al. Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng Part A, 2014, 20(11-12): 1632-1642.
[46]
46. Cosson S, Allazetta S, Lutolf M P,et al. Patterning of cell-instructive hydrogels by hydrodynamic flow focusing. Lab Chip, 2013, 13(11): 2099-2105.
[47]
47. Zheng Y, Chen J, Craven M,et al.In vitro microvessels for the study of angiogenesis and thrombosis. Proc Natl Acad Sci U S A, 2012, 109(24): 9342-9347.
[48]
48. Pringle S, Maimets M, van der Zwaag M,et al. Human salivary gland stem cells functionally restore radiation damaged salivary glands. Stem Cells, 2016, 34(3): 640-652.
