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-  2017 

肌腱干细胞在骨肌腱接点纤维软骨带重建中的作用机制研究进展

DOI: doi:10.7507/1002-1892.201612078

Keywords: 肌腱干细胞, 骨肌腱接点, 纤维软骨带, 重建

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Abstract:

目的 对肌腱干细胞(tendon-derived stem cells,TDSCs)在骨肌腱接点(bone-tendon junction,BTJ)纤维软骨带重建中的作用机制进行综述。 方法 广泛查阅国内外有关 TDSCs 促进 BTJ 纤维软骨带重建的研究文献,并总结分析。 结果 TDSCs 具有向骨细胞、纤维软骨细胞及肌腱细胞分化的能力,因此具备形成纤维软骨带的潜能;决定 TDSCs 成骨、成软骨分化的因素有力学刺激、生物活性因子、细胞外基质及炎性因子等。 结论 TDSCs 因其来源的特殊性,具有成为重建 BTJ 纤维软骨带种子细胞的潜能,通过外界刺激可诱导 TDSCs 形成类似于纤维软骨带结构

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