1. ?Luoma K, Riihim?ki H, Luukkonen R, et al. Low back pain in relation to lumbar disc degenerationc. Spine (Phila Pa 1976), 2000, 25(4): 487-492.
[2]
2. Hoy D, March L, Brooks P, et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis, 2014, 73(6): 968-974.
[3]
4. Kim DJ, Moon SH, Kim H, et al. Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine (Phila Pa 1976), 2003, 28(24): 2679-2684.
[4]
6. Du Y, Yip H. Effects of bone morphogenetic protein 2 on Id expression and neuroblastoma cell differentiation. Differentiation, 2010, 79(2): 84-92.
22. Detiger SE, Holewijn RM, Hoogendoorn RJ, et al. MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model. Eur Spine J, 2015, 24(9): 1935-1943.
[7]
23. Inoue H, Montgomery SR, Aghdasi B, et al. The effect of bone morphogenetic protein-2 injection at different time points on intervertebral disk degeneration in a rat tail model. J Spinal Disord Tech, 2015, 28(1): E35-44.
25. Kurooka H, Nakahiro T, Mori K, et al. BMP signaling is responsible for serum-induced Id2 expression. Biochem Biophys Res Commun, 2012, 420(2): 281-287.
[10]
3. Than KD, Rahman SU, Vanaman MJ, et al. Bone morphogenetic proteins and degenerative disk disease. Neurosurgery, 2012, 70(4): 996-1002.
[11]
5. Kim H, Lee JU, Moon SH, et al. Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. Spine (Phila Pa 1976), 2009, 34(17): 1834-1838.
[12]
8. Ren S, Liu Y, Ma J, et al. Treatment of rabbit intervertebral disc degeneration with co-transfection by adeno-associated virus-mediated SOX9 and osteogenic protein-1 double genes in vivo. IntJMolMed, 2013, 32(5): 1063-1068.
[13]
9. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine (Phila Pa 1976), 1995, 20(11): 1307-1314.
[14]
10. Nerlich AG, Schleicher ED, Boos N. 1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine (Phila Pa 1976), 1997, 22(24): 2781-2795.
[15]
11. Kalson NS, Richardson S, Hoyland JA. Strategies for regeneration of the intervertebral disc. Regen Med, 2008, 3(5): 717-729.
[16]
12. Li J, Yoon ST, Hutton WC. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech, 2004, 17(5): 423-428.
[17]
13. Wallach CJ, Sobajima S, Watanabe Y, et al. Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs. Spine (Phila Pa 1976), 2003, 28(20): 2331-2337.
[18]
14. Wang H, Kroeber M, Hanke M, et al. Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. J Mol Med (Berl), 2004, 82(2): 126-134.
[19]
15. Yoon ST, Park JS, Kim KS, et al. LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPsin vitro andin vivo. Spine (Phila Pa 1976), 2004, 29(23): 2603-2611.
[20]
16. Than KD, Rahman SU, Vanaman MJ, et al. Bone morphogenetic proteins and degenerative disk disease. Neurosurgery, 2012, 70(4): 996-1002.
[21]
17. Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci, 2000, 113(Pt 22): 3897-3905.
[22]
18. Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer, 2005, 5(8): 603-614.
[23]
19. Moon SH, Nishida K, Gilbertson LG, et al. Biologic response of human intervertebral disc cells to gene therapy cocktail. Spine (Phila Pa 1976), 2008, 33(17): 1850-1855.
[24]
20. Ren S, Liu Y, Ma J, et al. Treatment of rabbit intervertebral disc degeneration with co-transfection by adeno-associated virus-mediated SOX9 and osteogenic protein-1 double genesin vivo. IntJMolMed, 2013, 32(5): 1063-1068.
[25]
21. Ogon I, Takebayashi T, Takashima H, et al. Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc. J Orthop Sci, 2015, 20(2): 295-301.
[26]
26. Nakahiro T, Kurooka H, Mori K, et al. Identification of BMP-responsive elements in the mouse Id2 gene. Biochem Biophys Res Commun, 2010, 399(3): 416-421.
[27]
27. Somia N, Verma IM. Gene therapy: trials and tribulations. Nat RevGenet, 2000, 1(2): 91-99.
[28]
28. Wallach CJ, Kim JS, Sobajima S, et al. Safety assessment of intradiscal gene transfer: a pilot study. Spine J, 2006, 6(2): 107-112.