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-  2015 

雌激素及其受体在青少年特发性脊柱侧凸发病中作用的研究进展

DOI: doi:10.7507/1002-1892.20150308

Keywords: 青少年特发性脊柱侧凸, 雌激素, 月经初潮年龄, 基因多态性

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Abstract:

目的综述近年雌激素及其受体在青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)发病中作用的研究进展。 方法广泛查阅国内外与AIS病因中雌激素及其受体异常相关的临床资料与基础研究,并进行总结分析。 结果大多数AIS患者体内存在雌激素及其受体异常,主要包括血清雌激素水平升高、细胞对雌激素反应性异常、月经初潮年龄延迟及核受体与膜受体基因多态性,而且与侧凸的易感性、严重程度和进展风险密切相关。 结论雌激素及其受体通过不同病理机制在一定程度上参与了AIS的发生、发展,但机制尚不明确,仍有待进一步研究

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