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-  2015 

ErbB3和Flotillin-2在骨肉瘤中的表达及临床病理意义

DOI: doi:10.7507/1002-1892.20150128

Keywords: ErbB3, Flotillin-2, 骨肉瘤, 免疫组织化学

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Abstract:

目的探讨ErbB3和Flotillin-2在骨肉瘤中的表达及其相关性,并分析其临床意义。 方法取2009年9月-2014年3月收治的38例骨肉瘤患者和13例骨软骨瘤患者样本组织,行免疫组织化学染色。镜下观察ErbB3和Flotillin-2的表达情况,并统计分析二者在骨肉瘤和骨软骨瘤中阳性表达差异性、二者相关性及其与临床特征的关系。 结果镜下观察示,ErbB3、Flotillin-2蛋白均在骨肉瘤组织细胞质中高表达,其阳性率显著高于骨软骨瘤组织中(P<0.05)。ErbB3和Flotillin-2在骨肉瘤中的表达具有较好一致性(Kappa值=0.434,P=0.000)。ErbB3在骨肉瘤中表达与患者性别、年龄、肿瘤部位、肿瘤大小不相关(P>0.05),与美国国立综合癌症网络(NCCN)指南骨肉瘤临床分期及肺转移显著相关(P<0.05);而Flotillin-2在骨肉瘤中的表达与以上因素均无相关(P>0.05)。影响骨肉瘤患者总生存期的因素包括骨肉瘤临床分期、肺转移、ErbB3表达阳性及肿瘤大小(P<0.05),独立影响因素是肺转移和ErbB3表达阳性(P<0.05)。 结论ErbB3和Flotillin-2在骨肉瘤中过表达,且具有一致性。此外,ErbB3的表达与骨肉瘤临床分期和肺转移有关,肺转移和ErbB3过表达提示预后不佳

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