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- 2015

股骨隧道角度对兔前交叉韧带重建术后骨隧道影响的初步探讨

DOI: doi:10.7507/1002-1892.20150037

宋恩鸿,李张

Keywords: 前交叉韧带重建, 股骨隧道, TNF-α, 最大载荷

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Abstract:

目的探讨不同股骨隧道角度对兔前交叉韧带（anterior cruciate ligament,ACL）重建术后骨隧道愈合的影响。方法取4～5月龄健康家兔54只（雌雄不限，体重1.8～2.3 kg），随机分为3组（n=18）。3组均取右后肢自体跟腱制备ACL重建模型，重建时股骨隧道分别与股骨干纵轴在冠状位呈30、45、60°角定位；左膝关节作为正常对照。术后1、2、4周检测各组膝关节滑液中TNF-α含量，4、8、12周测量重建韧带最大载荷及骨隧道扩大率。结果与正常膝关节相比，3组术后各时间点膝关节滑液中TNF-α含量均显著增加，重建韧带最大载荷均降低，比较差异均有统计学意义（P＜0.05）；3组间比较差异均无统计学意义（P＞0.05）。3组术后各时间点均出现不同程度的股骨隧道扩大，4周时达最高值，但各时间点3组间股骨隧道扩大率比较，差异均无统计学意义（P＞0.05）。结论兔ACL重建中当股骨隧道与股骨干纵轴在冠状位呈30～60°间变化时，在早期对骨隧道愈合无明显影响

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