异香豆素噁二唑类化合物的合成及除草活性
Synthesis and herbicidal activity of several substituted isocoumarin oxadiazole

为了寻找具有较高除草活性的异香豆素类化合物，设计合成了16个新型异香豆素噁二唑类化合物4a～4p，其结构均经核磁共振氢谱、碳谱及高分辨质谱确证。初步除草活性测定结果表明，部分目标化合物在500 mg/L下对马唐Digitaria sanguinalis L.和反枝苋Amaranthusretroflexus L.具有一定的除草活性，其中化合物4j（4-[5-（4-氯-苯基）-[1，2，4]二唑-3-基]-3-己基-6，7-二甲氧基异香豆素）的活性最好，对马唐和反枝苋的致死率分别为64%和62%。
In order to get a series of isocoumarin compounds with high herbicidal activity, 16 substituted oxadiazole 4a-4p were synthesized. All the target compounds were characterized by 1H NMR, 13C NMR and HRMS. Preliminary screening with Digitaria sanguinalis L. and Amaranthus retroflexus L. demonstrated that some of the target compounds exhibited herbicidal activity at the concentrations of 500 mg/L. 4j, 4-(5-(4-chlorophenyl)-1, 2, 4-oxadiazol-3-yl)-3-hexyl-6, 7-dimethoxy-1H-isochromen-1-one had the best effect to D. sanguinalis and A. retroflexus of which the mortality rates were 64% and 62%.