COMT基因Val158Met多态性与同伴关系对青少年抑郁的影响
The Interaction between Val158Met Polymorphism in the COMT Gene and Peer Relationship on Adolescents' Depression

以1048名汉族青少年为被试，采用问卷法和基因分型技术，综合运用传统回归分析和新兴的再参数化回归分析，考察COMT基因Val158Met多态性与同伴关系对青少年抑郁的交互作用模式及其性别差异。结果发现，COMT基因与同伴接纳和同伴拒绝交互预测青少年抑郁，具体表现为，在低同伴接纳或高同伴拒绝环境中，携带ValVal基因型的青少年抑郁水平高于Met等位基因携带者；在高同伴接纳或低同伴拒绝环境中，携带ValVal基因型的青少年抑郁水平低于Met等位基因携带者。此外，COMT基因与同伴接纳和同伴拒绝的交互作用与男生抑郁的关联更加密切。结果显示，COMT基因与同伴关系的交互效应为不同易感性模型提供了证据，而且该基因×环境交互效应存在性别差异。
Catecholamine plays a central role in mood regulation and the development of depressive disorders.The present study investigated whether a functional polymorphism (Val158Met) of the catechol-O-methyltrans-ferase gene interacts with peer acceptance or peer rejection in the prediction of depression.A sample of 15 years old students (n=1,048,50% female) from a large longitudinal study of China were completed a questionnaire and gave a saliva sample for DNA extraction.When the whole population was analyzed,no main effects of COMT or peer relationship in association with depression were found.The COMT gene interacted with the two forms of peer relationships in predicting adolescent depression.Specifically,adolescents with ValVal homozygotes exhibited lower levels of depression when experiencing higher levels of peer acceptance or lower levels of peer rejection,but reported higher levels of depression when they were exposure to lower levels of peer acceptance or higher levels of peer rejection,relative to their counterparts with Met alleles.But there were no significant three-way interactions among gender,COMT gene and peer relationships on depression.When separated by gender,a significant G×E interaction effect of the ValVal genotype was found among boys.No G×E interaction effect was found among girls.The present study provides strong support for the differential susceptibility hypothesis.Besides,these findings highlight the importance of investigating the moderating role of gender and suggest that adolescent depression has complex genetic underpinnings which vary across genders.