静坐少动行为与中年人群心血管疾病风险因素的相关性
Correlation Between Sedentary Behavior and Cardiovascular Disease Risk Factors in Middle-Aged Adults

摘要：目的：探讨45~59岁人群中，静坐少动行为与心血管疾病风险因素之间的相关性。方法：随机招募愿意佩戴7 d加速度计的中年人群，客观测量一周体力活动水平，并采集血液样本。结果：中年人群中，静坐少动行为与躯干、下肢脂肪堆积和C-反应蛋白的相关性较密切且独立于MVPA（中等强度至较大强度体力活动）（P<0.05）；男性中，静坐少动行为与总胆固醇和LDL-C（低密度脂蛋白胆固醇）正相关（P<0.05）；女性中，静坐少动行为与空腹血糖、总胆固醇和LDL-C正相关（P<0.05），与HDL-C（高密度脂蛋白胆固醇）负相关（P<0.05）。结论：在中年人群中，静坐少动行为与躯干和下肢脂肪堆积、C反应蛋白和脂代谢之间具有负性的相关性且独立于MVPA；另外，静坐少动行为对女性的糖代谢也具有不利影响。
Abstract: Objective: The purpose of this study was to explore the correlation between sedentary behavior and various cardiovascular disease risk factors in 45-59 years old adults. Methods: Middle-aged participants were randomly recruited in this study and wore one week ActiGraph to measure physical activity, and blood samples were collected. Results: 1) In middle-aged adults, sedentary behavior is associated with fat accumulating in trunk and lower limbs and C-reactive protein independent of MVPA (P < 0.05). 2) Men’s sedentary behavior is positively related to total cholesterol and LDL-C (P < 0.05). 3) Women’s sedentary behavior is positively related to fasting blood glucose, total cholesterol and LDL-C (P < 0.05), and negatively related to HDL-C (P < 0.05). Conclusion: Independent of MVPA, sedentary behavior is negatively associated with adiposity distribution in trunk and lower limbs and C-reactive protein in middle-aged adults, and also it has negative effect on women’s glycometabolism