体力活动与癌症生存研究的10大问题
Top 10 Research Questions Related to Physical Activity and Cancer Survivorship

摘要：今天的美国有1 400万的癌症存活者，其中的很多存活者中都接受了多种治疗，包括手术、放疗、化疗、靶向治疗等。这些治疗能够延长生存时间，但同时也会带来很多急慢性的副作用，危害健康，影响生活质量。体力活动（PA）与癌症生存这一领域发展迅速，主要研究PA对癌症患者的影响。基于该领域的研究进展，提出了以下10大研究问题：1）PA能够降低癌症复发风险、和/或提高存活吗？2）PA能够影响癌症治疗决策、完成率、和/或患者对治疗的反应吗？3）癌症存活者的最佳运动处方是什么？4）静坐少动行为对癌症存活者有何影响？5）癌症存活者最有效的体力活动干预方案是什么？6）哪些癌症会影响病人对PA的反应？7）癌症存活者进行体力活动时需要注意的安全问题有哪些？8）哪些具体的癌症症状可以由PA解决？9）对于癌症晚期患者，体力活动还有何作用？10）如何将体力活动研究结果转化到临床和社区肿瘤实践中来？上述问题的回答至关重要，这不仅关系到体力活动和癌症存活这一研究领域的发展，更重要的是，能够为每年数百万新诊断为癌症的病人、正在接受癌症治疗的病人、治疗结束处于恢复中的病人或是那些正在与晚期癌症抗争的病人带来福音。
Abstract: In the United States, there are more than 14 million cancer survivors. Many of these survivors have been treated with multimodal therapy including surgery, radiation therapy, chemotherapy, and targeted therapies. These therapies improve survival; however, they also cause acute and chronic side effects that can undermine health and quality of life. Physical activity (PA) and cancer survivorship is a rapidly growing field of inquiry that studies the role of PA in people diagnosed with cancer. In this article, we propose the following top 10 research questions for the field of PA and cancer survivorship: 1) Does PA reduce the risk for cancer recurrence and/or improve survival? 2) Does PA influence cancer treatment decisions, completion rates, and/or response? 3) What is the optimal PA prescription for cancer survivors? 4) What is the role of sedentary behavior in cancer survivorship? 5) What are the most effective PA behavior change interventions for cancer survivors? 6) Which cancer variables modify the PA response? 7) What are the safety issues concerning PA in cancer survivors? 8) Which specific cancer symptoms can be managed by PA? 9) Is there a role for PA in advanced cancer? And 10) How do we translate PA research into clinical and community oncology practice? The answers to these questions are critical not only for advancing the field of PA and cancer survivorship, but for improving the lives of the millions of cancer survivors every year who are diagnosed with cancer, going through treatments, recovering after treatments, or coping with advanced disease