12周快步走对绝经后原发性高血压患者血清ET-1、NO及eNOS的影响
Effects of 12 Weeks Brisk Walking on Blood Pressure, ET-1, NO and eNOS in Postmenopausal Women with Essential Hypertension

摘要：目的：探讨有氧运动对绝经后女性原发性高血压人群的血压及血管内皮细胞分泌的NO、eNOS、ET-1的改善作用。方法：选取55～60岁绝经后女性，通过制定个性化的运动干预方案，进行12周的快步走锻炼。结果：运动锻炼组（TRG）的SBP较干预前显著性下降；血管内皮细胞分泌的NO、eNOS浓度显著高于干预前；ET-1浓度显著低于干预前。而不参与快步走锻炼的对照组（CON）的血压较干预前升高，NO和eNOS浓度较干预前下降，而ET-1较干预前升高，但均无统计学差异。结论：表明12周的快步走锻炼可以有效的控制绝经后女性血压的升高，并可能降低心血管患病风险。
Abstract: Purpose: The purpose of this study was to explore the effect of aerobic exercise on blood pressure and NO, eNOS and ET-1 secretion from vascular endothelial cells in postmenopausal women with essential hypertension. Methods: The 55-60 years old postmenopausal women were recruited in this study, and participated in a personalized 12-week fast walking exercise program. Results: After 12 weeks brisk walking, women’s SBP and ET-1 in exercise group significantly decreased; the concentrations of NO and eNOS secreted by endothelial cells in exercise group significantly increased. In control group, women’s SBP and ET-1 increased, the concentration of NO and eNOS decreased, but no significance. Conclusions: The 12-week brisk walking can effectively control the blood pressure in postmenopausal women and may reduce the risk of cardiovascular disease