体力活动与多发性硬化症研究的10大问题
Top 10 Research Questions Related to Physical Activity and Multiple Sclerosis

摘要：全世界约有250万人患有多发硬化症（MS），并且发病率有增加趋势。MS是一种中枢神经系统疾病，与多种症状和功能障碍相关。目前一线治疗方法对晚期患者基本无效。越来越多的证据表明体力活动（PA）有益于MS患者，但是大多数MS患者存在PA不足和静坐少动行为。因此，我们提出了10个研究问题，旨在指导今后有关PA和MS的研究：1）PA是否是一种MS的缓解性治疗行为？2）PA对MS患者有哪些益处？3）什么样的PA处方最适合MS患者？4）MS患者在PA中有哪些安全问题？5）哪些MS患者可以通过PA获得益处？6）哪些变量可以用来解释PA对MS患者的作用？7）有效促进 MS患者进行PA的行为干预方法是什么？8）我们如何将研究成果用于实际临床工作中？9）静坐少动行为对MS患者有什么影响？10）评价MS患者PA的最佳方法是什么？这些问题对于帮助我们了解PAPA对MS患者长期和短期的效果，开发新方法促进和保持MS患者的PA至关重要，解决这些问题可以大大改善MS患者的生活质量。
Abstract: An estimated 2.5 million people worldwide are living with multiple sclerosis (MS), and this disease may be increasing in prevalence. MS is a disease of the central nervous system that is associated with heterogeneous symptoms and functional consequences, and the current firstline disease-modifying therapies often become ineffective later in the disease. There is increasing evidence for the benefits of physical activity (PA) in people with MS, but this population is generally physically inactive and sedentary. We proposed 10 research questions to guide future research on PA and MS: (1) Is PA an MS disease-modifying behavior? (2) What are the benefits of PA among people with MS? (3) What is the optimal PA prescription for people with MS? (4) What are the safety issues with PA in people with MS? (5) What characteristics of people with MS modify the benefits of PA? (6) What variables explain participation in PA among people with MS? (7) What are effective behavioral interventions for PA change in people with MS? (8) How do we translate PA research into clinical MS practice? (9) What is the role of sedentary behavior in people with MS? And (10) what is the optimal measurement of PA in people with MS? These questions are critical for informing our understanding of the short- and long-term consequences of PA in MS as well as for identifying approaches for promoting and sustaining PA in MS. Addressing these questions may greatly improve the lives of people with this chronic disease