Aβ42对果蝇攻击和交配等社交行为的不同调节作用
Aβ42 differently regulates aggression and courtship behaviors in Drosophila

Aβ42（β-amyloid 42）蛋白聚集的毒性作用可能是阿尔兹海默病（Alzheimer’s disease，AD）的主要病因之一. 运用模式生物果蝇研究Aβ42可能对果蝇部分社交行为的影响. 首先，在Aβ42果蝇AD模型中观察到Aβ42在果蝇神经中枢蘑菇体区域的聚集和沉积. 然后，观察Aβ42果蝇的攻击性，实验发现Aβ42能加速首次攻击时间，并增加攻击频率等. 最后，观察Aβ42果蝇的交配行为. 实验证明，表达Aβ42可以增强中年果蝇攻击性行为，而对交配取向没有明显作用. 实验结果可为后续深入研究Aβ42对攻击性行为影响的神经环路和分子基础提供参考.
The accumulation of β-amyloid(Aβ) oligomers in the brain has strongly been implicated as one of primary events in the progression of AD（Alzheimer’s disease）. This study tested possible social interaction changes，including aggression and mating orientation by using a Aβ42 expressing Drosophila AD model. Firstly，the results confirmed that there were Aβ42 depositions in Aβ42 fly brains. Moreover，Aβ42 increased aggression behaviors in middle-aged flies，but not in young flies. Aβ42 significantly decreased aggression latency and increased frequency. Lastly，no mating orientation changes were found in Aβ42 flies at different ages. Results demonstrated that Aβ42 expression increased aggression behaviors in flies，but without changing mating orientation