|
- 2015
诱导性多能干细胞(iPSCs)在牙再生中的应用
|
Abstract:
摘要 干细胞能够自我更新并分化成各类组织细胞,在再生医学中具有很大的应用潜力。随着组织工程的快速发展,以胚胎干细胞和组织干细胞为基础的牙再生技术有待成为替代缺失牙的一种重要方法,然而免疫排斥和伦理的争议等问题为干细胞的临床应用带来很大的困难。由自体细胞产生的诱导性多能干细胞的发现将为牙齿再生带来革命性变化。本文就诱导性多能干细胞的研究背景及其在再生医学和牙再生领域的应用进展作一综述
[1] | N. Montserrat, E. Nivet, I. Sancho-Martinez, et al .Reprogramming of human broblasts to pluripotency with lineage specifiers [J]. Cell Stem Cell, 2013, 13(3)∶341-350 |
[2] | F. Gonzalez, S. Boue, J.C. Izpisua Belmonte, Methods for making induced pluripo-tent stem cells: reprogramming a la carte [J]. Nat. Rev. Genet, 2011,12(4)∶231-242 |
[3] | C.A. Sommer, M. Stadtfeld, G.J. Murphy, et al. Induced pluripotent stem cell generation using a single lentiviralstem cell cassette [J]. Stem Cells, 2009,27(3)∶543-549 |
[4] | Kim H, Stan ,G, Mark B. iPSC for Dental Tissue Regeneration [J]. Kim Current Oral Health Reports, 2014, 1(1)∶9-15 |
[5] | Ardeshirylajimi A, Dinarvand P, Seyedjafari E, et al. Enhanced reconstruction of rat calvarial defects achieved by plasma-treated electrospun scaffolds and induced pluripotent stem cells [J]. Cell Tissue Res, 2013, 354(3)∶849-60 |
[6] | Nait Lechguer A, Couble ML, Labert N , et al. Cell differentiation and matrix organization in engineered teeth [J]. Dent. Res,2011,90(5)∶583-589 |
[7] | Kim K, Doi A, Wen B, et al. Epigenetic memory in induced pluripotent stem cells [J]. Nature, 2010, 467(7313)∶285-90[21] Polo JM, Liu S, Figueroa ME, et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripo-tent stem cells [J]. Nat Biotechnol, 2010, 28(8)∶848-55 |
[8] | Otsu K., Kishigami R., Oikawa-Sasaki A, et al. Differentiation of induced pluripotent stem cells into dentalmesenchymal cells [J]. Stem Cells,2012,21(7)∶1156-1164 |
[9] | Arakaki M, Ishikawa M, Nakamura T, et al. Role of epithelial-stem cell interactions during dental cell differentiation [J]. J Biol Chem,2012,287(13)∶10590-601 |
[10] | Cai J, Zhang Y, Liu P, et al. Generation of tooth-like structures from intergration-free human urine induced pluripotent stem cells [J]. Cell Regen, 2013, 2-6 |
[11] | Kishigami R, Otsu K, Oikawa-Sasaki A, et al. Histological analysis of epithelial stem cells during induced pluripotent stem cell-derived teratoma development [J]. Oral Biosci,2012,54∶58-65 |
[12] | 秦彤,苗向阳.iPS细胞研究的新进展及应用[J].遗传,2010,12∶1205-1214 |
[13] | 王亦菁,张晓东,于华,等.体外成牙环境对牙髓干细胞和外胚间充质干细胞分化的影响[J].华西口腔医学杂志,2012,30(6)∶579-583 |
[14] | Ogonuki N, Inoue K., Yamamoto Y, et al. Early death of mice cloned from somatic cells [J]. Nat. Genet,2002,30(3)∶253-254 |
[15] | Hynes K, Menicanin D, Han J, et al. Mesenchymal stem cells from iPS cells facilitate periodontal regeneration [J]. J Dent Res,2013,92(9)∶833-9 |
[16] | Y.S. Chun, P. Chaudhari, Y.Y. Jang, et al.Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease [J]. Int. J. Biol. Sci, 2010, 6(7)∶796-805 |
[17] | K. Okita, T. Yamakawa, Y. Matsumura, et al .An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells [J]. StemCells,2013,31(3)∶458-466 |
[18] | Tamaoki N, Takahashi K, Tanaka T, et al. Dental pulp cells for induced pluripotent stem cell banking [J]. Dent. Res, 2010, 89(8)∶773-778 |
[19] | K. Okita, H. Hong, K. Takahashi, et al. Generation of mouse-induced plurip-otent stem cells with plasmid vectors [J]. Nat. Protoc, 2010, 5(3)∶418-428 |
[20] | M. Li, I. Sancho-Martinez, J.C. Izpisua Belmonte, Cell fate conversion by mRNA [J]. Stem Cell Res. Ther,2011,2∶5 |
[21] | Ebert A , Liang P, Wu C. Induced pluripotent stem cells as adisease modeling and drug screening platform [J]. J Cardiovasc Pharmacol. 201260, (4)∶408-416 |
[22] | Wada N, Wang B, Lin N. H,et al. Induced pluripotent stem cell lines derived from human gingival fibroblasts and periodontal ligament fibroblasts [J]. Periodont Res, 2011, 46(4)∶438-447 |
[23] | Lee G, Papapetrou E P, Kim H, et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs [J]. Nature, 2009, 461(7262)∶402-406 |
[24] | Duan X, Tu Q, Zhang J, et al. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration [J]. J Cell Physiol,2011,226(1)∶150-7 |
[25] | Minina IuM, Zhdanova NS, Shilow AG, et al. Chromosomal instability of in vitro cultured mouse embryonic stem cells and induced pluripotent stem cells [J]. Tsitologiia,2010,52(5)∶420-425 |
[26] | Lian Q, Zhang Y, Zhang J, et al. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limbischemia in mice [J]. Circulation, 2010, 121(9)∶1113-23 |
[27] | Otsu K, Kumakami M,Fujiwara N,et al.Stem cell sources for tooth regeneration :current status and future prospects [J]. Front Physio,2014,5∶36 |
[28] | Takahashi K ,Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factor [J]. Cell, 2006, 126(4)∶663-676 |
[29] | Hochedlinger K, Jaenisch R. Nuclear reprogramming and pluripotency [J]. Nature,2006, 441(7097)∶1061-1067 |
[30] | Ferreira, L ,Mostajo-Radji M. How induced pluripotent stem cells are redefining personalized medicine [J]. Gene, 2013, 520(1)∶1-6 |