|
|
- 2015
放射照射后牵张成骨下牙槽神经电生理变化的实验研究
|
Abstract:
摘要 目的:探讨放射照射后牵张成骨过程中下牙槽神经的电生理变化。方法:12只中国杂种犬随机分为A、B、C三组,A、B、C组为实验组,每组4只,单侧下颌A组接受总剂量22.8 Gy,5.7 Gy/4次/2周(相当于50 Gy/25次/5周),B组接受总剂量24.8 Gy,6.2 Gy/4次/2周(相当于60 Gy/30次/6周),C组接受总剂量27.2 Gy,6.8 Gy/4次/2周(相当于70 Gy/35次/7周)的60Co放射照射。放射照射完成后3个月时,各组分别于照射区下颌骨切开,置入牵张器。经五天延迟期,以0.5 mm/次,2次/d的速度牵张下颌骨10 d,然后固定8周。分别于放疗前、放疗结束后、牵张前、牵张第6天、牵张完成即时、固定第2,4,8周8个时间点以神经电生理检诊仪测定神经电生理变化。结果:50 Gy和60 Gy组牵张过程中动作电位呈现适应性变化,70 Gy组不能完整导出动作电位。结论:低剂量放射照射不会单独对牵张过程中神经电生理变化造成影响,高剂量放射照射不能完成电生理检查
| [1] | Liu Y,Liu G,Liu Y,Lin X. Character of distracted bone in irradiated canine mandibles and electrophysiological changes in the inferior alveolar nerve [J]. Br J Oral Maxillofac Surg, 2010, 48(2)∶115-120 |
| [2] | ]Ilizarov GA. The tension-stress effect on the genesis and growth of tissues.Part II:the influence of the rate and frequency of distraction [J]. Clin orthop,1989,239∶263-285 |
| [3] | Liu Y, Liu G, Xu J, et al. Distraction osteogenesis in the dog mandibles under 60Gy irradiation [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2012, 113(2)∶183-187 |
| [4] | Mizumoto Y, Mizuta H, Nakamura E, et al. Tibial nerve function during tibial lengthening:measurement of nerve conduction and blood flow in rabbits [J]. Acta Orthop Scand,1995,66∶275-277 |
| [5] | Jskelinen SK, Teerijoki-Oksa T, Virtanen A, et al. Sensory regeneration following intraoperatively verified trigeminal nerve injury [J]. Neurology, 2004, 62(11)∶1951-7 |
| [6] | Thygesen TH,Baad-Hansen L,Svensson P.Sensory action potentials of the maxillary nerve:a methodologic study with clinical implications [J]. J Oral Maxillofac Surg,2009,67(3)∶537-542 |
| [7] | Nocini PF, De Santis D, Fracasso E, et al. Clinical and electrophysiological assessment of inferior alveolar nerve function after lateral nerve transposition [J]. Clin Oral Implants Res,1999,10(2)∶120-130 |
| [8] | 周诺,韦山良,蒙宁,等.下颌骨牵张成骨对下牙槽神经影响的实验研究[J].口腔医学,2004,24(6)∶321-324 |
