|
|
- 2017
拔牙位点保存用复合温敏凝胶的构建及体外表征
|
Abstract:
摘要 目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/ HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS /MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10 g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441 MPa),所获复合温敏凝胶具有适宜的临床操作时间(12 min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景
| [1] | Dang QF, Yan JQ, Li JJ, et al. Controlled gelation temperature, pore diameter and degradation of a highly porous chitosan-based hydrogel [J]. Carbohydrate Polymers, 2011, 83(1)∶171-178 |
| [2] | Yang BX, Li Y, Shi S, et al. Preparation and characterization of a novel chitosan scaffold [J]. Carbohydrate Polymers, 2010, 80(3)∶860-865 |
| [3] | Li M. In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide [J]. J.mater.chem.b, 2012, 1(4)∶475-484 |
| [4] | Avila-Ortiz GS, Elangovan K, Kramer WO, et al. Effect of Alveolar Ridge Preservation after Tooth Extraction: A Systematic Review and Meta-analysis [J]. Journal of Dental Research, 2014, 93(10)∶950-958 |
| [5] | 邱泽文,刘慧颖,仲维剑,等.拔牙窝填塞Bio-oss人工骨对延期种植骨结合影响的组织学观察[J].口腔医学研究,2015,31(1)∶1-3 |
| [6] | Tolstunov L. Implant zones of the jaws: implant location and related success rate [J]. The Journal of oral implantology, 2007, 33(4)∶211-220 |
| [7] | 王一波,李云鹏,侯锐,等.人脐带间充质干细胞在壳聚糖温敏凝胶中增殖和成骨分化的实验研究[J].口腔医学研究,2015,31(1)∶38-40 |
| [8] | Lei SY, Tao, G, Ping, et al. Incorporation of cisplatin into PEG-wrapped ultrapurified large-inner-diameter MWCNTs for enhanced loading efficiency and release profile [J] International Journal of Pharmaceutics, 2014, 471(s1-2)∶157-165 |
| [9] | Zhang, W, S.S.L. And, and F.Z. Cui, Hierarchical Self-Assembly of Nano-Fibrils in Mineralized Collagen [J]. Chemistry of Materials, 2003, 15(16)∶3221-3226 |
| [10] | Hortigüela, M.J, M.C. Gutiérrez, I. Aranaz, et al. Urea assisted hydroxyapatite mineralization on MWCNT/CHI scaffolds [J]. Journal of Materials Chemistry, 2008, 18(48)∶5933-5940 |
| [11] | Núez JD, Benito AM, González R, et al. Integration and bioactivity of hydroxyapatite grown on carbon nanotubes and graphene oxide [J]. Carbon, 2014, 79(1)∶590-604 |
| [12] | Hutmacher DW. Scaffolds in tissue engineering bone and cartilage [J]. Biomaterials, 2000, 21(24)∶2529-2543 |
| [13] | Blanes RJ, Bernard JP, Blanes ZM, et al. A 10-year prospective study of ITI dental implants placed in the posterior region. I: Clinical and radiographic results [J]. Clinical Oral Implants Research, 2007, 18(6)∶699-706 |
| [14] | Chenite AC, Chaput D, Wang, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ [J]. Biomaterials, 2000, 21(21)∶2155-2161 |
