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- 2017
牙周炎与冠心病之间联系机制的研究进展
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Abstract:
摘要 牙周炎已成为成人失牙的首要原因,调查显示全球约有44％~57％和10％的成人患有中度和重度牙周炎。而冠状动脉粥样硬化性心脏病(CHD)是临床上死亡率较高的疾病之一,严重危害着人类健康,其主要病理学基础是动脉粥样硬化(AS)和在斑块破裂基础上形成的血栓。牙周炎和冠心病之间存在着一定的联系,牙周致病菌通过直接作用定植在冠状动脉;通过间接作用产生各种细胞因子、黏附分子,引起全身炎症状态、脂质异常和凝血状态;激活固有免疫系统,分别形成生物性炎症、化学性炎症、免疫性炎症,最终形成和加重动脉粥样硬化,继而形成冠心病。本文旨在对牙周炎与冠心病之间联系机制的研究进展作一综述
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