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- 2018
CD29的表达与人类唾液腺良恶性肿瘤发病关系的研究
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Abstract:
摘要 目的:分析与明确各种细胞表面标记物的表达和分布,特别是CD29在成人唾液腺中的表达和分布。方法:采集成对的成人腮腺、舌下腺和颌下腺组织。并使用免疫组化检测收集的腺体中各种家族特异性细胞表面标记的表型表达(包括CD29)。结果:发现CD29在唾液腺腺泡和导管上皮,间充质基质和肌上皮细胞上均有表达;CD29+细胞在成人唾液腺上皮中与CD324、CD326、NKCC1和CD44共表达;间充质细胞主要表达CD73、CD90、波形蛋白和CD34而α-SMA主要是肌上皮细胞特异性祖细胞标记物。结论:CD29广泛表达于人唾液腺中,可作为唾液腺疾病和恶性肿瘤新型细胞治疗和诊断的潜在生物标志物
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