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- 2016
微生态制剂及抗菌肽在龋病防治中的研究进展
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Abstract:
摘要 龋病是以细菌因素为主的多种因素引起的口腔微生态失衡为特征的口腔慢性感染性疾病,是人类最常见的细菌性疾病[1,2]。目前龋病预防的关注点集中于对牙菌斑的去除,而牙菌斑实则为大量共生微生物集中组成,因此"移除或杀灭所有"菌斑微生物的理念对于致病微生物创造了一个开放的非竞争性的环境。传统的方法预防或治疗龋病,无法从根本上解决牙体组织损伤及细菌耐药性等问题。微生态制剂及抗菌肽应运而生,通过抑制口腔病原菌毒性作用以达到调节口腔微生态平衡的目的,是预防及治疗龋病的新方法
| [1] | Wu G, Bazer FW, Davis TA, et al. Arginine metabolism and nutrition in growth,health and disease [J]. Amino Acids, 2009, 37∶153-168 |
| [2] | Cagetti MG, Mastroberardino S, Milia E, et al. The Use of Probiotic Strains in Caries Prevention A Systematic Review [J]. Nutrients,2013,5(7)∶2530-2550 |
| [3] | Chong ES. A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action [J]. World J Microbiol Biotechnol, 2014, 30∶351-374 |
| [4] | Reid G, Bruce AW, Fraser N, et al. probiotics can resolve urogenital infections [J]. FEMS Immunol Med Microbiol, 2001, 30∶49-52 |
| [5] | Terai T, Okumura T, Imai S, Nakao M, Yamaji K, Ito M, et al. Screening of Probiotic Candidates in Human Oral Bacteria for the Prevention of Dental Disease [J]. PLoS ONE,2015,10(6)∶e0128657 |
| [6] | Marttinen A, Haukioja A, Karjalainen S, et al. Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque [J]. Clin Oral Investig,2012,16∶797-803 |
| [7] | Singh RP, Damle SG, Chawla A, et al. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5 [J]. Acta Odontol Scand,2011,69∶389-394 |
| [8] | Bhushan J, Chachra S. Probiotics. Their Role in Prevention of Dental Caries [J]. J Oral Health Comm Dent,2010,4(3)∶78-82 |
| [9] | W. Pan, T. Mao, Q. Xu, et al.A New gcr R - Deficient Streptococcus mutans Mutant for Replacement Therapy of Dental Caries [J]. The Scientific World Journal,2013,2013∶1-7 |
| [10] | Wade WG . The oral microbiome in health and disease [J]. Pharmacological Research, 2013, 69(1)∶138-143 |
| [11] | Saini R, Saini S, Sharma S. Potential of probiotics in controlling cardiovascular diseases [J]. Cardiovasc Dis Res,2010,1∶213-214 |
| [12] | Raman M, Ambalam P, Kondepudi KK, et al. Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer [J]. Gut Microbes, 2013, 4∶181-192 |
| [13] | Nascimento MM, Gordan VV, Garvan CW, et al. Correlations of oral bacterial arginine and urea catabolism with caries experience [J]. Oral Microbiol Immunol, 2009, 24∶89-95 |
| [14] | Chuang LC, Huang CS, Ou-Yang LW,et al. Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora [J]. Clin Oral Investig,2011,15∶471-476 |
| [15] | Bhardwaj A, Bhardwaj SV. Role of Probiotics in Dental Caries and Periodontal Disease [J]. Archive of Clinical and Experimental, 2012, 43(1)∶45-49 |
| [16] | Sharif MO, Iram S, Brunton PA Effectiveness of argininecontaining toothpastes in treating dentine hypersensitivity: a systematic review [J]. J Dent ,2013, 41∶483-492 |
| [17] | World Health Organization: Oral health fact sheet N°318.2012 In: Centre, M (ed.) |
| [18] | Gungor OE, Kirzioglu Z, Kivanc M. Probiotics: can they be used to improve oral health [J]. Beneficial Microbes, 2015, 47(1)∶1-10 |
| [19] | Masdea L, Kilik EM, Hauser-Gerspach, et al. Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodou [J]. Archives of oral biology, 2012, 57∶1041-1047 |
| [20] | Jindal G, Pandey RK, Agarwal J,et al. A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children [J]. Eur Arch Paediatr Dent, 2011, 12∶211-215 |
| [21] | Chuang LC, Huang CS, Ou-Yang LW, et al. Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora [J]. Clin Oral Investig, 2011, 15∶471-476 |
| [22] | Onnida Wattanarat, Anupong Makeudom, Thanapat Sastraruji, et al. Enhancement of salivary human neutrophil peptide 1 - 3 levels by probiotic supplementation [J]. BMC Oral Heath,2015,15∶19 |
| [23] | Singh RP, Damle SG, Chawla A. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5 [J]. Acta Odontol Scand, 2011, 69∶389-394 |
| [24] | unni. Mai, X.L. Tian, J.W. Gallant, et al. A Novel Target-Specific, Salt-Resistant Antimicrobial Peptide against the Cariogenic Pathogen Streptococcus mutans [J]. Antimicrobial Agents And Chemotherapy,2011,55(11)∶5205-5213 |
| [25] | Kaplan CW, Sim JH, Shah KR, et al. Selective membrane disruption: mode of action of C16G2, a specifically targetedantimicrobial peptide [J]. Antimicrobial Agents And Chemotherapy,2011,55(7)∶3446-3452 |
