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- 2018
不同正畸治疗措施对错牙合畸形患者龈沟液MMP-2、TIMP-2水平的影响分析
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Abstract:
摘要 目的:分析不同正畸治疗措施对错牙合畸形患者龈沟液基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)、金属蛋白酶组织抑制物-2(tissue inhibitors of metalloproteinases-2,TIMP-2)水平的影响。方法:选取医院收治的错牙合畸形患者60例,按照随机数字表法分为A组、B组、C组和D组,每组各15例。所有患者均接受正畸治疗,4组患者分别给予0、50、150 g和250 g的远中移动初始力。比较4组患者治疗前及治疗1、2、3、4周龈沟液MMP-2、TIMP-2水平及其比值。结果:治疗1、2、3、4周后,B组、C组沟液MMP-2、TIMP-2水平显著高于A组和D组,且C组MMP-2、TIMP-2水平显著高于B组,差异有统计学意义(P＜0.05);B组和C组龈沟液MMP-2/TIMP-2比值治疗1周后明显升高,治疗2、3、4周后呈现小幅度降低趋势;A组和D组治疗前后沟液MMP-2、TIMP-2水平比较差异均无统计学意义。结论:龈沟液中MMP-2、TIMP-2水平与正畸力的大小以及持续时间有关,而且龈沟液MMP-2、TIMP-2动态水平变化可作为分析正畸牙加力的重要参考指标
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