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- 2018
超重小鼠应对牙周感染的血清炎症因子反应
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Abstract:
摘要 目的:探索超重宿主应对牙周感染的系统性免疫反应。方法:将28只C57 BL/6J小鼠分为高脂(HFD)和低脂饲料(LFD)组,HFD诱导超重模型,LFD作为正常体重对照。诱导8周时,两饲料组均再分为牙周炎(P)和健康(C)组(n=7),P组做牙周结扎,C组做对照。10 d后处死,Micro-CT分析骨丧失线性分数,蛋白芯片筛检血清中20个炎症因子水平,单因素方差分析比较4组间差异。结果:HFD组的体重高于LFD组3.8 g(15.5%)(P<0.01)。P组的骨丧失线性分数显著高于C组(P< 0.01)。除HFDP组的 IL-6水平较LFDC组显著上调外(P<0.05),其他炎症因子反应在HFD与LFD组间无显著差异,在HFD小鼠的P组与C组间亦无差异。结论:未发现系统性炎症介导超重与牙周炎的相互关系
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