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- 2018
1型糖尿病小鼠下颌密质骨厚度特点的研究
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Abstract:
摘要 目的:运用Micro-CT对1型糖尿病小鼠颌骨密质骨厚度的改变进行研究。方法:选用6周龄小鼠20只,随机分为对照组和糖尿病组,糖尿病组按50 mg/kg剂量连续5 d腹腔内注射链脲佐菌素建立1型糖尿病小鼠模型,对照组腹腔注射枸橼酸盐缓冲液。饲养12周后处死小鼠,取全血进行血清钙磷检测;通过Micro-CT扫描小鼠下颌骨比较糖尿病组和对照组密质骨厚度的特点。结果:糖尿病组血清钙水平较对照组降低,血清磷水平升高,钙磷乘积下降。Micro-CT观察到糖尿病组小鼠密质骨厚度较对照组明显变薄,两组密质骨厚度的比较差异有统计学意义(P<0.01)。结论:本实验通过链脲佐菌素诱导的1型糖尿病小鼠密质骨结构发生了改变,Micro-CT结果显示糖尿病状态下颌骨密质骨厚度明显变薄
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