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-  2018 

基因治疗骨关节病的研究进展
Research Progress of Gene Therapy on Osteoarthrosis.

DOI: 10.13701/j.cnki.kqyxyj.2018.03.004

Keywords: 骨关节病,基因治疗,颞下颌关节,
Osteoarthrosis
,Gene therapy,Temporomandibular joint

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Abstract:

摘要 骨关节病是常见的以软骨损伤为特征的关节退行性疾病,目前的治疗方法较多,但大多实施困难且效果不佳。颞下颌关节骨关节病作为一种常见的口腔颌面疾病,其修复与治疗对临床和科研工作者具有挑战性。基因治疗是近年发展起来的一项新兴诊疗技术,因其对软骨生物学性能的潜在修复力而逐渐引起人们重视。它主要涉及到靶细胞、目的基因、载体这三方面的问题,本文就此作一综述

References

[1]  Hung GL, Galea-Lauri J, Mueller GM, et al. Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin -1 receptor antagonist gene to synovium [J]. Gene Ther, 1994, 1(1)∶64-69
[2]  K Chen, C Man, B Zhang, et al. Effect of in vitro chondrogenic differentiation of autologous mesenchymal stem cells on cartilage and subchondral cancellous bone repair in osteoarthritis of temporomandibular joint [J]. Int J Oral Maxillofac Surg, 2013, 42(2)∶240-248
[3]  MF Pittenger, AM Mackay, SC Beck, et al. Multilineage potential of adult human mesenchymal stem cells [J]. Science, 1999, 284(5411)∶143-147
[4]  Shi S, Mercer S. Growth factor transgenes interactively regulate articular chondrocytes [J]. J Cell Biochemistry, 2013, 114(4)∶908-919
[5]  Rey-Rico A, Frisch J, Schmitt G, et al. PEO-PPO-PEO carriers for rAAV-mediated transduction of human articular chondrocytes in vitro and in a human osteochondral defect model [J]. ACS Appl Master Interfaces, 2016, 8(32)∶20600-20613
[6]  Madry H, Cucchiarini M. Gene therapy for human osteoarthritis: principles and clinical translation, 2016, 16(3)∶331-346
[7]  马绪臣,张震康.颞下颌关节紊乱病的命名、诊断分类及治疗原则[J].中华口腔医学杂志,2002,37(4)∶241-243
[8]  Demange MK, Sisto M, Rodeo S. Future trends for unicompartmental arthritis of the knee: Injectables and & stem cells. Clinics in sports medicine, 2014 , 33(1)∶161-174
[9]  CH Jo, YG Lee, WH Shin, et al. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial [J]. Stem cells, 2014, 32(5)∶1254-1266
[10]  Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells [J]. Mol Biol Cell, 2002, 13∶4279-4295
[11]  Yoon IS, Chung CW, Sung JH, et al. Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold [J]. J Biosci Bioeng, 2011,112∶402-408
[12]  Zhang P, Zhong ZH, Yu HT, et al. Exogenous expression of IL-1a and TGF-β1 promotes in vivo repair in experimental rabbit osteoarthritis [J]. Scand J Rheumatol, 2015, 44(5)∶404-411
[13]  邓末宏,孟庆功,龙星. β1型整合素在兔颞下颌关节骨关节病组织中的表达变化[J].口腔医学研究,2011,27(7)∶564-567
[14]  Garza-Veloz I, Romero-Diaz VJ, Martinez-Fierro, et al. Analyses of chondrogenic induction of adipose mesenchymal stem cells by combined co-stimulation mediated by adenoviral gene transfer [J]. Arthritis Res Ther, 2013, 15(4)∶R80
[15]  Pisal DS, Kosloski MP, Balu-Iyer SV. Delivery of therapeutic proteins [J]. Pharm Sci, 2010, 99(6)∶2557-2575
[16]  Rekha MR, Sharma CP. Polymers for gene delivery: current status and future perspectives [J]. Recent Patents on DNA & Gene Sequences, 2012,6(2)∶98-107
[17]  Sukarto A, Yu C, Flynn LE, et al. Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair [J]. Biomacromolecules,2012,13(8)∶2490-2502
[18]  Yao Y, Zhang F, Pang PX, et al. In vitro study of chondrocyte redifferentiation with lentiviral vector-mediated transgenic TGF-3 and shRNA suppressing type I collagen in three-dimensional culture [J]. J Tissue Eng Regen Med, 2011, 5(8)∶219-227
[19]  Hemphill DD, Mcllwraith CW, Slaycten RA, et al. Adeno-associated virus gene therapy vector scAAVIGF-1 for transduction of equine articular chondrocytes and DNA-seq analysis [J]. Osteoarthritis cartilage, 2016, 24(5)∶902-911
[20]  Zhao J,Fan X, Zhang Q, et al. Chitosan-plasmid DNA nanoparticles encoding small hairpin RNA targeting MMP-3 and-13 to inhibit the expression of dedifferentiation related genes in expanded chondrocytes [J]. J Biomed Mater Res A, 2014,102(2)∶373-380
[21]  Che JH, Zhang ZR, Li GZ, et al. Application of tissue engineered cartilage with BMP-7gene to repair knee jointcartilage injury in rabbits [J]. Knee Surg Sports Traumatol Arthrosc, 2010, 18(4)∶496-503
[22]  Shi S, Mercer S, Eckert GJ, et al. Growth factor regulation of growth factor production by multiple gene transfer to chondrocytes [J]. Growth Factors, 2013, 31(1)∶32-38
[23]  Madry H, Kaul G, David Zurakowski, et al.Cartilage constructs engineered from chondrocytes Overexpressing IGF-1 improved the repair of osteochondral defects in a rabbit model [J]. Eur Cell Master, 2013, 25∶229-247
[24]  Cucchiarini M, Ekici M, Schetting, et al. Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2 [J]. Tissue Engineering Part A,2011,17∶1921-1933
[25]  Carreira AC, Lojudice FH, Halcsik E, et al. Bonemorphogenetic proteins:facts, challenges, and Future respectives [J]. J Dent Res, 2014, 93∶335-345
[26]  Steinert AF, Weissenberger M, Kunz M,et al. Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells [J]. Arthritis Res Ther,2012,14(4)∶R168
[27]  Gabner S, Hlavaty J, Velde K. Inflammation-induced transgene expression in genetically engineered equine mesenchymal stem cells [J]. J Gene Med, 2016(8)∶154-164
[28]  杨兴华,彭琳,刘云生,等.骨髓间充质干细胞移植治疗颞下颌关节骨关节病[J].中国组织工程研究,2013(19)∶3488-3494

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