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- 2016
整合素连接激酶和一氧化氮合酶在口腔鳞状细胞癌中的表达及意义
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Abstract:
摘要 目的:探讨整合素连接激酶(ILK)和一氧化氮合酶(NOS)在口腔鳞状细胞癌(OSCC)中的表达及意义。方法:收集71例择期行手术切除治疗的OSCC患者肿瘤组织及癌旁组织,利用免疫组化SP法对ILK、eNOS和iNOS在肿瘤组织及癌旁组织中表达进行检测。结果:ILK、eNOS和iNOS在癌旁组织中阳性表达率分别为39.4%、45.1%和29.6%,且主要以弱阳性为主,而在OSCC组织中阳性表达率分别为98.6%、93.0%和95.8%,且以强阳性表达为主,ILK、eNOS和iNOS在OSCC组织中阳性表达显著高于癌旁组织,差异均有统计学意义(P<0.05);ILK和iNOS在OSCC组织中表达均与分化程度和淋巴结转移有关(P<0.05);Spearman相关分析显示,ILK在OSCC组织中强表达与iNOS强表达呈正相关(r=0.529,P=0.000)。结论:ILK、eNOS和iNOS在OSCC组织中出现高表达,可能通过促进肿瘤中血管生成而参与OSCC细胞浸润和转移过程
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