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- 2016
复合纳米银托槽粘接剂在大鼠龋病模型上抗菌性的研究
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Abstract:
摘要 目的:评价复合纳米银托槽粘接剂在大鼠口内的抗菌活性。方法:利用大鼠龋病模型来模拟人的口腔环境,将托槽底板用复合纳米银托槽粘接剂粘结在上颌第一双尖牙颊侧的半边牙冠表面,再将其结扎固定在大鼠口腔下前牙舌侧的根部,分别在植入手术后的1个月和3个月时间段局麻下取25个样本牙,通过扫描电镜定期观察材料表面变形链球菌定植情况。结果:成功构建了大鼠龋病模型。通过长期的观察发现,材料样本牙放置的位置没有对其正常进食造成影响,材料几乎没有发生脱落现象。扫描电镜结果显示,Transbond XT表面变形链球菌生长活跃,层层堆积;植入1个月后的GC Fuji ORTHO LC表面变链菌零星分布或少量成簇,3个月后数量明显增多并呈链状;在NSC2,NSC3和NSC4组的两个观察期,随着纳米银含量的增加,变链菌的数量呈现减少的趋势,而且形态趋于分散单个存在。结论:纳米银的加入在某种程度上增强了粘结剂对变链菌的黏附抑制和杀灭作用
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